ArticleCancers2022
Association of Allostatic Load and All Cancer Risk in the SWAN Cohort.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality.Proteomes · 2026Article
- Allostatic Load, Multimorbidity, and Overall and Cancer-Specific Survival among Older Adults in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Impact of Allostatic Load on Overall Survival in Patients With Endometrial Cancer.Cancer medicine · 2026Article
- Association between allostatic load and risk of breast carcinoma in situ in the UK biobank.Cancer causes & control : CCC · 2026Article
- Association Between Allostatic Load and Incident Colorectal Cancer-A Prospective Study in a Multiethnic Asian Population.Cancer medicine · 2026Article
- Socioeconomic disparities in long-term heart failure risk of trastuzumab with or without anthracyclines in early-stage breast cancer: a SEER-Medicare database analysis.NPJ breast cancer · 2026Article
- Exploratory analysis of allostatic load and mortality in patients with hepatocellular carcinoma.BMC research notes · 2026Article
- Allostatic load, personality traits, and cancer risk: A prospective cohort study.Psychological medicine · 2026Article
- Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression.International journal of biological sciences · 2026Review
- Allostatic load and risk of prostate cancer in UK Biobank.Scientific reports · 2025Article
- Disparities in Allostatic Load Among Different Races: A Comprehensive Scoping Review.Journal of racial and ethnic health disparities · 2025Review
- Allostatic load and kidney cancer incidence and mortality: a genetic susceptibility and proteomic mediation analysis.BMC cancer · 2025Article
- Current insights into breast and ovarian cancer risk: a contemporary review.Minerva surgery · 2025Review
- Allostatic Load and Racial and Rural Disparities in Breast Cancer Survival.JAMA network open · 2025Article
- Allostatic load and cancer risk, progression, and mortality in epidemiologic studies.American journal of epidemiology · 2025Article
- Allostatic load score and lifestyle factors in the SWAN cohort: A longitudinal analysis.Public health in practice (Oxford, England) · 2025Article
- The Interplay of Chronic Stress and Cancer: Pathophysiology and Implications for Integrated Care.Cancer reports (Hoboken, N.J.) · 2025Review
- Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort.BMJ open · 2025Article
- Association between education and allostatic load with risk of cancer mortality among Hispanic women.Social science & medicine (1982) · 2025Article
- Association of allostatic load with functional disability in the China Health and Retirement Longitudinal Study.The journal of nutrition, health & aging · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Elevated chronic stress is thought to increase cancer risk, though the results so far have been inconsistent. In this study, we assessed the relationship between allostatic load (AL), a biological indicator of chronic stress, and overall cancer risk in 3015 women who participated in the Study of Women’s Health Across the Nation (SWAN). Based on the distribution of AL, the study population was categorized into four groups, from the lowest (1st category) to the highest AL group (4th category). At baseline, African American and Hispanic women were more likely to be in the higher AL categories than White women (p < 0.001). In addition, women who smoked regularly, drank alcohol regularly, had no leisure physical activity, and had restless sleep were also more likely to be in the higher AL categories than their relative counterparts (p < 0.001). We also observed that women in the lower-income category with no health insurance were more likely to be in the higher AL category (p < 0.001). The study then found that women in the 4th category of AL (the highest AL group) had a 1.64-fold increased risk of overall cancer (Hazard ratio (HR): 1.64, 95% confidence interval (CI): 1.04, 2.59). The risk association was further strengthened after adjusting demographics, healthy behaviors, and socioeconomic factors with an HR of 2.08. In further analysis of individual biomarkers of AL score, we found that higher levels of triglyceride and CRP were associated with increased risk of cancer, highlighting the role of metabolic dysfunction and inflammation in the etiology of cancer development. In summary, we report that higher AL is associated with increased cancer risk.
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