ArticleAnimals : an open access journal from MDPI2022
Dietary Glutamine Supplementation Alleviated Inflammation Responses and Improved Intestinal Mucosa Barrier of LPS-Challenged Broilers.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The effects of glutamine supplementation on inflammatory and oxidative stress indices in chronic diseases: a systematic review.Amino acids · 2026Pooled it
- Effects of Immunologically Active Peptides on Growth Performance, Meat Quality, Antioxidant Capacity, and Ileum Inflammation in Broilers.Veterinary sciences · 2026Article
- Silphium perfoliatum flavonoids alleviate LPS-induced injury via enhancing intestinal antioxidant capacity, barrier function, and regulating cecal microbiota in broilers.Poultry science · 2026Article
- Alleviating the Adverse Effects of Lipopolysaccharide on Production Performance, Immune Function, and Intestinal Damage in Broilers via Dietary Alkaline Phosphatase.Animals : an open access journal from MDPI · 2026Article
- Comparative study on the effects of glutamic acid and glutamine in promoting intestinal development in chicks through energy metabolism.Animal bioscience · 2026Article
- Classification of intestinal inflammation driven by gut microbiota metabolites: a new paradigm for precision treatment of cardiovascular diseases.Frontiers in microbiology · 2026Review
- Chlorogenic Acid Alleviates Ferroptosis Collectively Induced by Lipopolysaccharide and Interleukin-6 in Bovine Mammary Epithelial Cells.Journal of agricultural and food chemistry · 2025Article
- Time-course analysis of the effect of paraprobiotics ABG0050 on the intestinal immune system of broilers.Poultry science · 2025Article
- Effects of glutamine supplementation on the growth performance, antioxidant capacity, immunity and intestinal morphology of cold-stressed prestarter broiler chicks.Veterinary research communications · 2025Article
- Effects of Alanyl-Glutamine Dipeptide Supplementation on Growth Performance, Nutrient Digestibility, Digestive Enzyme Activity, Immunity, and Antioxidant Status in Growing Laying Hens.Animals : an open access journal from MDPI · 2024Article
- Prebiotics enhance the immunomodulatory effect ofFood science & nutrition · 2024Article
- Effects of Sea-Buckthorn Flavonoids on Growth Performance, Serum Inflammation, Intestinal Barrier and Microbiota in LPS-Challenged Broilers.Animals : an open access journal from MDPI · 2024Article
- Effects of Chinese Gallotannins on Antioxidant Function, Intestinal Health, and Gut Flora in Broilers Challenged withAnimals : an open access journal from MDPI · 2024Article
- Polysaccharide of Atractylodes macrocephala Koidz alleviates LPS-induced proliferation, differentiation inhibition and excessive apoptosis in chicken embryonic myogenic cells.Veterinary medicine and science · 2024Article
- The Effects of Glutamine Supplementation on Liver Inflammatory Response and Protein Metabolism in Muscle of Lipopolysaccharide-Challenged Broilers.Animals : an open access journal from MDPI · 2024Article
- The Bidirectional Link between Nutritional Factors and Inflammatory Bowel Diseases: Dietary Deficits, Habits, and Recommended Interventions-A Narrative Review.Foods (Basel, Switzerland) · 2023Review
- Glutamine alleviated heat stress-induced damage of porcine intestinal epithelium associated with the mitochondrial apoptosis pathway mediated by heat shock protein 70.Journal of animal science · 2023Article
- Protective role of Cecropin AD against LPS-induced intestinal mucosal injury in chickens.Frontiers in immunology · 2023Article
- Lipopolysaccharide-induced immune stress negatively regulates broiler chicken growthFrontiers in immunology · 2023Article
- Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The present study was conducted to investigate the effects of glutamine (Gln) supplementation on intestinal inflammatory reaction and mucosa barrier of broilers administrated with lipopolysaccharide (LPS) stimuli. A total of 120 1-d-old male broilers were randomly divided into four treatments in a 2 × 2 experimental arrangement, containing immune challenge (injected with LPS in a dose of 0 or 500 μg/kg of body weight) and dietary treatments (supplemented with 1.22% alanine or 1% Gln). The results showed that growth performance of broilers intra-abdominally injected with LPS was impaired, and Gln administration alleviated the adverse effects on growth performance induced by LPS challenge. Furthermore, Gln supplementation reduced the increased concentration of circulating tumor necrosis factor-α, interleukin-6 and interleukin-1β induced by LPS challenge. Meanwhile, D-lactic acid and diamine oxidase concentration in plasma were also decreased by Gln supplementation. In addition, the shorter villus height, deeper crypt depth and the lower ratio of villus height to crypt depth of duodenum, jejunum and ileum induced by LPS stimulation were reversed by Gln supplementation. Gln administration beneficially increased LPS-induced reduction in the expression of intestine tight junction proteins such as zonula occludens protein 1 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.