ArticleAnimals : an open access journal from MDPI2022
High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers.
Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- A review of the iron requirements and its determination in commercial poultry.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Nutritive Constituents' Variation in Main Parts of Dendrocalamus Brandisii and the Silage Fermentation for Bamboo-Based Ruminant Feed.Applied biochemistry and biotechnology · 2026Article
- HIF-2α could be a key regulator of Fe homeostasis in the gut of yellow-feathered broilers.Poultry science · 2026Article
- Diet-vaccine interactions: SQM Iron andApplied and environmental microbiology · 2026Article
- Joint Transcriptomic Analysis of the Effect of Iron Concentration on Piglet Liver and Functional Validation of Iron Regulatory Genes.Current issues in molecular biology · 2025Article
- Effects of Dietary Iron Levels on the Production Performance, Nutrient Digestibility, Blood Biochemistry, and Meat and Fur Quality of Growing Rex Rabbits.Animals : an open access journal from MDPI · 2025Article
- Changes of metabolic parameters, antioxidant capacity, and gut microbiota in response to substitution of ferrous sulfate with iron hydroxy methionine analog chelate in weaned piglets.Frontiers in cellular and infection microbiology · 2025Article
- A novel consensus bacterial 6-phytase variant supplemented to an all-vegetable broiler diet totally replaced added trace minerals including zinc, iron, copper and manganese in two experiments.Poultry science · 2025Article
- Levels of substitution of inorganic mineral to amino acids complexed minerals on old laying hens.Scientific reports · 2024Article
- Concentrations, Sources, and Health Risk of Heavy Metals in Edible Parts of Broilers from Northeast of Algeria.Biological trace element research · 2024Article
- Dietary contribution of iron from limestone and dicalcium phosphate for broiler chickens.Poultry science · 2024Article
- Effects of Iron Oxide Nanoparticle Supplementation on the Growth Performance, Serum Metabolites, Meat Quality, and Jejunal Basal Morphology in Broilers.Animals : an open access journal from MDPI · 2023Article
- Iron requirements of broiler chickens as affected by supplemental phytase.Journal of animal science · 2023Article
- Integrated evaluation of the requirements and excretions of Cu, Fe, Zn, and Mn for broilers via a uniform design method.Frontiers in veterinary science · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although Iron (Fe) is an essential nutrient that plays a vital role in respiratory processes, excessive Fe in the diet can affect the health of broilers. We investigated the effects of diet supplemented with high levels of iron chelates with lysine and glutamic acid (Fe−LG) on the growth performance, serum biochemical parameters, antioxidant status, and duodenal mRNA expression of Fe transporters in broilers. A total of 800 1-day-old male Arbor Acres broilers were assigned to 5 groups, with 8 replicates each. Broilers were fed a corn−soybean meal basal diet or basal diets supplemented with 40, 80, 400, or 800 mg Fe/kg as Fe−LG for 6 weeks. The body weight (BW) was increased in the 80 mg Fe/kg treatment group, but decreased in the 800 mg Fe/kg treatment group on day 21. During days 1−21, compared with the control group, the supplementation of the 80 mg Fe/kg increased the average daily gain (ADG) and average daily feed intake (ADFI); however, the supplementation of the 800 mg Fe/kg group decreased the ADG and increased the FCR in broilers (p < 0.05). The heart, liver, spleen, and kidney indices were reduced in the 800 mg Fe/kg treatment group (p < 0.05). The supplementation of the 800 mg Fe/kg group increased the serum aspartate aminotransferase activity and the levels of creatinine and urea nitrogen on day 42 (p < 0.05). The broilers had considerably low liver total superoxide dismutase activity and total antioxidant capacity in the 800 mg Fe/kg treatment group (p < 0.05). Serum and liver Fe concentrations were elevated in the 400 and 800 mg Fe/kg treatment groups, but were not affected in the 40 and 80 mg Fe/kg treatment groups. The duodenal Fe transporters divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) were downregulated in the Fe−LG treatment groups (p < 0.05). We conclude that a high dietary supplement of 800 mg Fe/kg in broilers leads to detrimental health effects, causing kidney function injury and liver oxidative stress.
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