ArticleCritical care (London, England)2022
Extended prone positioning duration for COVID-19-related ARDS: benefits and detriments.
Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05124197 (Safety and Efficacy of a Strategy Extending Duration of Prone Position in COVID-19-related ARDS Patients. a Retrospective Monocentric Observational Study), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of a Strategy Extending Duration of Prone Position in COVID-19-related ARDS Patients. a Retrospective Monocentric Observational Study
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Effectiveness and safety of prolonged prone positioning in adult patients with acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Persistent Features of Laryngeal Injury Following Endotracheal Intubation: A Systematic Review.Dysphagia · 2023Pooled it
- Optimal Prone Position Duration in Patients With ARDS Due to COVID-19: The Omelette Pilot Trial.Respiratory care · 2024Trial
- Article
- Reply to "PROVENT-C19 repeated prone positioning analysis": not everything that differs is inconsistent.Journal of anesthesia, analgesia and critical care · 2026Article
- Protective Ventilation During Controlled and Partial Ventilatory Support in ARDS: Clinical-Physiological Background and Monitoring.Journal of clinical medicine · 2026Review
- Time-dependent effects in consecutive cycles of prone positioning for acute respiratory failure: insights from the PROVENT-C19 Registry.Journal of anesthesia, analgesia and critical care · 2026Article
- Integrating ultra-prolonged prone ventilation with mechanical power monitoring in refractory acute respiratory distress syndrome (ARDS): a case report.Frontiers in medicine · 2026Article
- Pulmonary and Extrapulmonary Effects of Prolonged Prone Positioning in a Porcine Model of Acute Respiratory Distress Syndrome.Shock (Augusta, Ga.) · 2025Article
- Post-acute sequelae SARS-CoV-2 infection and neuropathic pain: a narrative review of the literature and future directions.Pain management · 2025Review
- The effects of prolonged prone positioning on response and prognosis in patients with acute respiratory distress syndrome: a retrospective cohort study.Journal of intensive care · 2025Article
- The effect of high lateral position on antibiotic exposure duration in patients with severe traumatic brain injury: a retrospective observational cohort study.Frontiers in medicine · 2025Article
- Extended versus Standard Proning Duration for COVID-19-associated Acute Respiratory Distress Syndrome: A Target Trial Emulation Study.Annals of the American Thoracic Society · 2024Article
- Extended Prone Position and 90-Day Mortality in Mechanically Ventilated Patients With COVID-19.Respiratory care · 2024Article
- Respiratory effects of prone position in COVID-19 acute respiratory distress syndrome differ according to the recruitment-to-inflation ratio: a prospective observational study.Annals of intensive care · 2024Article
- Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19.Annals of intensive care · 2024Article
- Effect of awake prone positioning on tracheal intubation rates in patients with COVID-19: A meta-analysis.Heliyon · 2023Review
- Extended prone positioning for intubated ARDS: a review.Critical care (London, England) · 2023Review
- Prone Positioning in Mechanically Ventilated COVID-19 Patients: Timing of Initiation and Outcomes.Journal of clinical medicine · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the COVID-19 pandemic, many more patients were turned prone than before, resulting in a considerable increase in workload. Whether extending duration of prone position may be beneficial has received little attention. We report here benefits and detriments of a strategy of extended prone positioning duration for COVID-19-related acute respiratory distress syndrome (ARDS).
methodsA eetrospective, monocentric, study was performed on intensive care unit patients with COVID-19-related ARDS who required tracheal intubation and who have been treated with at least one session of prone position of duration greater or equal to 24 h. When prone positioning sessions were initiated, patients were kept prone for a period that covered two nights. Data regarding the incidence of pressure injury and ventilation parameters were collected retrospectively on medical and nurse files of charts. The primary outcome was the occurrence of pressure injury of stage ≥ II during the ICU stay.
resultsFor the 81 patients included, the median duration of prone positioning sessions was 39 h [interquartile range (IQR) 34-42]. The cumulated incidence of stage ≥ II pressure injuries was 26% [95% CI 17-37] and 2.5% [95% CI 0.3-8.8] for stages III/IV pressure injuries. Patients were submitted to a median of 2 sessions [IQR 1-4] and for 213 (94%) prone positioning sessions, patients were turned over to supine position during daytime, i.e., between 9 AM and 6 PM. This increased duration was associated with additional increase in oxygenation after 16 h with the PaO
conclusionIn patients with extended duration of prone position up to 39 h, cumulative incidence for stage ≥ II pressure injuries was 26%, with 25%, 2.5%, and 0% for stage II, III, and IV, respectively. Oxygenation continued to increase significantly beyond the standard 16-h duration. Our results may have significant impact on intensive care unit staffing and patients' respiratory conditions.
trial registrationInstitutional review board 00006477 of HUPNVS, Université Paris Cité, APHP, with the reference: CER-2021-102, obtained on October 11th 2021. Registered at Clinicaltrials (NCT05124197).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.