Evidence map›Paper›PMID 35804452›Full record

ArticleTrials2022

A prospective trial to evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with arsenic trioxide and carboplatin in locally advanced cervical cancer: a study protocol for randomized controlled clinical.

Ze Yang He, Hai Ying Li, Jiao Yan, Si Jin Li, Dao Cheng Li, Zhong Zhe Liang

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ze Yang He *Department of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. 609394689@qq.com.ORCID http://orcid.org/0000-0002-6895-093X
Hai Ying Li *Department of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Jiao YanDepartment of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Si Jin LiDepartment of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Dao Cheng LiDepartment of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhong Zhe LiangDepartment of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
First Affiliated Hospital of Guangzhou University of Chinese Medicine · CN

Funding

Traditional Chinese Medicine Bureau of Guangdong Province 20194005
6 · The paper itself

Abstract

backgroundCervical cancer is the fourth most common malignancy in women, which is threatening female reproductive tract health. Chemotherapy can be used for neoadjuvant therapy of locally advanced cervical cancer and postoperative adjuvant therapy for patients with high-risk factors, so as to reduce the focus, sensitize radiotherapy, and reduce recurrence. The current first-line treatment is paclitaxel combined with platinum. Many literature studies have found that As

methodsSixty participants in the IB2, IIA2, and IIB stages of cervical cancer will be recruited in this study. After excluding patients who did not meet the criteria, they were randomly assigned to two groups in a 1:1 ratio. All patients underwent colposcopic biopsies to confirm the diagnosis and detailed clinical examinations. Eligible patients will receive either 2 cycles of paclitaxel and carboplatin or As DISCUSSION: This is the first single-center, prospective, two-arm design, open-label randomized control trial that will evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with As

trial registrationChineseClinicalTrialRegistry ChiCTR1900023822 . Registered on 13 June 2019.

Indexed as

Neoadjuvant TherapyUterine Cervical NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsArsenic TrioxideCarboplatinChemotherapy, AdjuvantFemaleHumansNeoplasm StagingPaclitaxelPlatinumProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeArsenic TrioxideCarboplatinPaclitaxelPlatinumArsenic trioxide (AS2O3)CarboplatinCervical cancerNeoadjuvant chemotherapyPaclitaxelProtocolRandomized controlled trial

Identifiers

PMID35804452
PMCPMC9270736
OpenAlexW4284965721

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.