Evidence map›Paper›PMID 35804408›Full record

SynthesisItalian journal of pediatrics2022

The global prevalence of autism spectrum disorder: a comprehensive systematic review and meta-analysis.

Nader Salari, Shabnam Rasoulpoor, Shna Rasoulpoor, Shamarina Shohaimi, Sima Jafarpour, Nasrin Abdoli, Behnam Khaledi-Paveh, Masoud Mohammadi

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Italian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05868720 (EFFECT OF RISPERIDONE vs ARIPIPRAZOLE ON OXIDATIVE STRESS IN PATIENTS WITH AUTISM SPECTRUM DISORDER), which is not on this map. Cited by 252 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 14 pooled it
49.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05868720 naunknown statusnot on this mapstarted 2023, after this paper: background citation

EFFECT OF RISPERIDONE vs ARIPIPRAZOLE ON OXIDATIVE STRESS IN PATIENTS WITH AUTISM SPECTRUM DISORDER: A RANDOMIZED CONTROLLED TRIAL

TypeinterventionalSponsorAll India Institute of Medical Sciences, BhubaneswarRan2023 to 2025Enrolled42ConditionsThe Goal of This Trial is to to Compare the Effect of Risperidone vs Aripiprazole in Terms of Change in Serum Glutathione LevelArmsRisperidone, Aripiprazole
3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 14 syntheses or guidelines pooled it, 456 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Recognition of the microbial metaboliteFrontiers in molecular neuroscience · 2025
    Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Article
  20. Article

192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Nader SalariDepartment of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Shabnam RasoulpoorDepartment of Psychiatric Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran.
Shna RasoulpoorStudent research committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Shamarina ShohaimiDepartment of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia.
Sima JafarpourDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Nasrin AbdoliDepartment of Psychiatry, Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Behnam Khaledi-PavehSleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Masoud MohammadiCellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran. Masoud.mohammadi1989@yahoo.com.ORCID http://orcid.org/0000-0002-5722-8300
Kermanshah University of Medical Sciences · IRUrmia University · IRGerash University of Medical Sciences · IRIsfahan University of Medical Sciences · IRUniversiti Putra Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) is one of the serious developmental disorders that is usually diagnosed below the age of three years. Although the severity of the disease's symptoms varies from patient to patient, the ability to communicate with others is affected in all forms of ASD. This study aimed to determine the prevalence of ASD in high-risk groups by continent.

methodsThe present study was conducted by systematic review and meta-analysis from 2008 to July 2021. Databases such as Science Direct, PubMed, Scopus, SID, Magiran, Web of Science (WoS), and Google Scholar from 2008 to July 2021 were searched to find related studies. Data were analysed using Comprehensive Meta-Analysis software (Version 2).

resultsA total of 74 studies with 30,212,757 participants were included in this study. The prevalence of ASD in the world was 0.6% (95% confidence interval: 0.4-1%). Subgroup analyses indicated that the prevalence of ASD in Asia, America, Europe, Africa and Australia was 0.4% (95% CI: 0.1-1), 1% (95% CI: 0.8-1.1), 0.5% (95% CI: 0.2-1), 1% (95% CI: 0.3-3.1), 1.7% (95% CI: 0.5-6.1) respectively.

conclusionASD imposes a heavy health burden on communities around the world. Early detection of ASD can reduce the incidence of developmental disorders and improve patients' communication skills. Therefore, health policymakers need to be aware of the prevalence and increasing trend of ASD to implement appropriate planning and interventions to reduce its consequences.

Indexed as

Autism Spectrum DisorderChild, PreschoolEuropeHumansPrevalenceASDAutism spectrum disordermeta-analysisPrevalencesystematic review

Identifiers

PMID35804408
PMCPMC9270782
OpenAlexW4284962360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.