ArticleNature communications2022
Electrochemical aromatic C-H hydroxylation in continuous flow.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- Photocatalytic Anaerobic Conversion of m-Xylene to Xylenols With Co-Production of Hydrogen.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Electrochemical hydroxylation of alkenes with HNational science review · 2026Article
- Review
- Dearomative syn-1,4-hydroalkylation and C(spNature chemistry · 2026Article
- Flow Reactor for Sustainable Electrosynthesis Fabricated via Cost-Effective Electroplating and Adhesive Bonding.ChemSusChem · 2025Article
- Electrolyte-Controlled Regiodivergent Continuous Flow Electroselenocyclisations.Angewandte Chemie (International ed. in English) · 2025Article
- Identification of Key Active-Site Positions Controlling the Chemoselectivity of Aspergillus Brasiliensis Unspecific Peroxygenase.Chembiochem : a European journal of chemical biology · 2025Article
- C3 Selective Hydroxylation of Pyridines via Photochemical Valence Isomerization of PyridineJournal of the American Chemical Society · 2024Article
- Tailoring photocatalysts to modulate oxidative potential of anilides enhances para-selective electrochemical hydroxylation.Nature communications · 2024Article
- Automation and machine learning augmented by large language models in a catalysis study.Chemical science · 2024Review
- Direct C-H Hydroxylation ofJournal of the American Chemical Society · 2024Article
- Continuous flow synthesis enabling reaction discovery.Chemical science · 2024Review
- Synthesis of meta-carbonyl phenols and anilines.Nature communications · 2024Article
- A review of recent advances in electrochemical and photoelectrochemical late-stage functionalization classified by anodic oxidation, cathodic reduction, and paired electrolysis.Beilstein journal of organic chemistry · 2024Review
- Electrochemical Late-Stage Functionalization.Chemical reviews · 2023Review
- The crucial role of silver(I)-salts as additives in C-H activation reactions: overall analysis of their versatility and applicability.Chemical Society reviews · 2023Review
- Polymer up-cycling by mangana-electrocatalytic C(spChemical science · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The direct hydroxylation of arene C-H bonds is a highly sought-after transformation but remains an unsolved challenge due to the difficulty in efficient and regioselective C-H oxygenation and high reactivity of the phenolic products leading to overoxidation. Herein we report electrochemical C-H hydroxylation of arenes in continuous flow for the synthesis of phenols. The method is characterized by broad scope (compatible with arenes of diverse electronic properties), mild conditions without any catalysts or chemical oxidants, and excellent scalability as demonstrated by the continuous production of 1 mol (204 grams) of one of the phenol products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.