ArticleNature communications2022
Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Observing hidden neuronal states in experiments.PLoS computational biology · 2025Article
- Curcumin attenuates neuroinflammation and improves cognitive function in a rat model of febrile convulsions.Scientific reports · 2025Article
- Resilience of circuits to environmental challenge.Current opinion in neurobiology · 2024Review
- How neuronal morphology impacts the synchronisation state of neuronal networks.PLoS computational biology · 2024Article
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5 authors.
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Abstract
Almost seventy years after the discovery of the mechanisms of action potential generation, some aspects of their computational consequences are still not fully understood. Based on mathematical modeling, we here explore a type of action potential dynamics - arising from a saddle-node homoclinic orbit bifurcation - that so far has received little attention. We show that this type of dynamics is to be expected by specific changes in common physiological parameters, like an elevation of temperature. Moreover, we demonstrate that it favours synchronization patterns in networks - a feature that becomes particularly prominent when system parameters change such that homoclinic spiking is induced. Supported by in-vitro hallmarks for homoclinic spikes in the rodent brain, we hypothesize that the prevalence of homoclinic spikes in the brain may be underestimated and provide a missing link between the impact of biophysical parameters on abrupt transitions between asynchronous and synchronous states of electrical activity in the brain.
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