Evidence map›Paper›PMID 35803877›Full record

ArticleReproductive biomedicine online2022

COVID-19 mRNA vaccines have no effect on endometrial receptivity after euploid embryo transfer.

Pedro Brandão, Antonio Pellicer, Marcos Meseguer, José Remohí, Nicolás Garrido, Juan Antonio García-Velasco

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biomedicine online, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Effect of COVID-19 vaccination on the outcome ofFrontiers in public health · 2023
    Pooled it
  3. Pooled it
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Female reproduction and abnormal uterine bleeding after COVID-19 vaccination.Clinical and experimental reproductive medicine · 2023
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Pedro BrandãoDepartment of Reproductive Medicine, IVIRMA Lisboa, H 1- 9ª, Avenida Infante Dom Henrique 333, Lisbon 1800-282, Portugal; Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, Portugal. Electronic address: pedro.brandao@ivirma.com.
Antonio PellicerDepartment of Reproductive Medicine, IVIRMA Roma, Largo Ildebrando Pizzetti, 1/Piano 1 Interno 2, Rome 00197, Italy; IVI Foundation, Instituto de Investigación Sanitaria La Fe, Valencia, Spain, Avenida Fernando Abril Martorell, 106 - Biopolo, Torre A, Planta 1ª, Valencia 46026, Spain.
Marcos MeseguerIVI Foundation, Instituto de Investigación Sanitaria La Fe, Valencia, Spain, Avenida Fernando Abril Martorell, 106 - Biopolo, Torre A, Planta 1ª, Valencia 46026, Spain; Department of Reproductive Medicine, IVIRMA Valencia, Plaza de la Policia Local 3, Valencia 46015, Spain.
José RemohíIVI Foundation, Instituto de Investigación Sanitaria La Fe, Valencia, Spain, Avenida Fernando Abril Martorell, 106 - Biopolo, Torre A, Planta 1ª, Valencia 46026, Spain; Department of Reproductive Medicine, IVIRMA Valencia, Plaza de la Policia Local 3, Valencia 46015, Spain.
Nicolás GarridoIVI Foundation, Instituto de Investigación Sanitaria La Fe, Valencia, Spain, Avenida Fernando Abril Martorell, 106 - Biopolo, Torre A, Planta 1ª, Valencia 46026, Spain.
Juan Antonio García-VelascoIVI Foundation, Instituto de Investigación Sanitaria La Fe, Valencia, Spain, Avenida Fernando Abril Martorell, 106 - Biopolo, Torre A, Planta 1ª, Valencia 46026, Spain; Department of Reproductive Medicine, IVIRMA Madrid, Av. del Talgo, 68, Madrid 28023, Spain; University Rey Juan Carlos, C. Tulipán, Móstoles Madrid 28933, Spain.
Instituto de Investigación Sanitaria La Fe · ESValencian Infertility Institute · ESInstituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

research questionDoes the COVID-19 vaccination affect endometrial receptivity after single euploid embryo transfer, measured by sustained implantation rate?

designA retrospective cohort study analysing two groups of single euploid embryo transfers using own oocytes: one historical cohort of 3272 transfers 1 year before the pandemic; and one comprising 890 transfers in women previously vaccinated with mRNA vaccines against severe acute respiratory syndrome coronavirus 2. The main outcomes were clinical pregnancy rate (CPR) and sustained implantation rate (SIR) per embryo transfer. These outcomes were compared between non-vaccinated and vaccinated women, and women who had received one and two doses. Lastly, vaccinated women were divided into quartiles according to the time from last dose to embryo transfer.

resultsSimilar CPR and SIR were found between non-vaccinated and vaccinated women, and the odds ratio for both outcomes was not statistically significant after being controlled for potential confounders (OR 0.937, 95% CI 0.695 to 1.265 and OR 0.910, 95% CI 0.648 to 1.227 respectively). Within the vaccinated group, women who had received one or two doses also had similar outcomes. In addition, no differences were found according to the time interval from vaccination to embryo transfer.

conclusionThe administration of mRNA vaccines against COVID-19 had no effect on endometrial receptivity and embryo implantation, regardless of the number of doses and time interval from vaccination to embryo transfer. The potential negative effect of the vaccine on endometrial receptivity and reproductive outcomes is reassuring for patients in the process of undergoing assisted reproductive treatment.

Indexed as

COVID-19COVID-19 VaccinesEmbryo ImplantationEmbryo TransferFemaleHumansmRNA VaccinesPregnancyPregnancy RateRetrospective StudiesVaccines, SyntheticCOVID-19 VaccinesmRNA VaccinesVaccines, SyntheticCOVID-19 vaccines, embryo implantation, clinical pregnancy rate, assisted reproductive techniquesSARS-CoV-2Single embryo transfer

Identifiers

PMID35803877
PMCPMC9148433
OpenAlexW4281887135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.