ArticleLife science alliance2022
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.
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Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
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Who cites it
37 citing papers in PubMed, 45 citations in OpenAlex.
- Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer.Cancer discovery · 2026Article
- DB-2B, a Novel and Selective STAT3 Inhibitor Inhibits Colorectal Cancer Progression In Vitro and In Vivo.Biomolecules · 2026Article
- Hypoxic Tumor Microenvironment Targeting: Opportunities and Challenges for Pancreatic Cancer Immunotherapy.International journal of molecular sciences · 2026Review
- Hypoxia-Induced Fibroblast IL-6 Promotes Immunosuppressive Macrophage Phenotypes in Pancreatic Cancer.Cells · 2026Article
- Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression.Cancer research · 2026Article
- Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation.Cancer research · 2026Article
- Clinical Application Progress of Artificial Intelligence in Pancreatic Cancer: From Diagnosis to Immunotherapy.Oncology research · 2026Review
- CAF-derived exosomes: orchestrators of dysregulated signaling pathways in breast cancer progression.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Innate immunity-stroma crosstalk in pancreatic cancer: overcoming spatial and metabolic barriers to immunotherapy.Frontiers in immunology · 2026Review
- Post-Translational Modifications: Key "Regulators" of Pancreatic Cancer Malignant Phenotype-Advances in Mechanisms and Targeted Therapies.Biomedicines · 2025Review
- CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Review
- Review
- Review
- Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery.Journal of cell communication and signaling · 2025Review
- Tumor-associated macrophages (TAMs): Constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC).Cancer pathogenesis and therapy · 2025Review
- STAT3 Signaling Pathway in Health and Disease.MedComm · 2025Review
- The multi-faceted roles of cancer-associated fibroblasts in pancreatic cancer.Cellular signalling · 2025Review
- Molecular mechanism of pancreatic ductal adenocarcinoma: The heterogeneity of cancer-associated fibroblasts and key signaling pathways.World journal of clinical oncology · 2025Review
- PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition.International journal of biological sciences · 2025Article
- Profiling of collagen and extracellular matrix deposition from cell culture using in vitro ExtraCellular matrix mass spectrometry imaging (ivECM-MSI).Matrix biology plus · 2024Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Julia E LeflerHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Catherine B MarElia-BennettHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-5751-9634
Katie A ThiesHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Blake E HildrethHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Sudarshana M SharmaHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Jason R PitarresiDivision of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Lu HanHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Caroline EverettHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-7492-6258
Christopher KoivistoHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Maria C CuitinoHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Cynthia D TimmersHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Elizabeth O'QuinnHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Melodie ParrishHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Martin J RomeoHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Amanda J LinkeHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
G Aaron HobbsHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Gustavo LeoneDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
Denis C GuttridgeDepartment of Pediatrics and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.
Teresa A ZimmersDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Gregory B LesinskiDepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Michael C OstrowskiHollings Cancer Center and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA ostrowsk@musc.edu.ORCID 0000-0003-2948-6297
Medical University of South Carolina · USEmory University · USIndiana University School of MedicineMedical College of Wisconsin · USUniversity of Pennsylvania · US
Funding
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7MThe role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Hailong Zhang · 2020 to 2026
$18.7MSuppression of Mammary Tumorigenesis by Stromal p53P01CA097189 · NCI · OHIO STATE UNIVERSITY · PI ROSOL, THOMAS J · 2004 to 2016
$16.1MProteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8MIntegrative Training in Oncogenic SignalingT32CA193201 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HOWE, PHILIP H, LONG, DAVID THOMAS · 2016 to 2025
$3.7MMUSC Post-Baccalaureate Research Education ProgramR25GM113278 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DELEON-PENNELL, KRISTINE Y, PENROD-MARTIN, RACHEL · 2015 to 2024
$2.7MEnhancing immune therapy in pancreatic cancer by targeting IL-6R01CA208253 · NCI · OHIO STATE UNIVERSITY · PI LESINSKI, GREGORY B. · 2016 to 2021
$1.6MMacrophage and osteoclast specific targeting for the prevention and treatment of breast cancer bone metastasisK01OD026527 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HILDRETH, BLAKE EASON · 2018 to 2022
$634kInvestigating sliding clamps and their contribution to genome stabilityF31CA254328 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MAGRINO, JOSEPH · 2021 to 2023
$70kTumor tissue crosstalk in the macroenvironment of pancreatic cancer cachexiaI01CX002046 · VA · RLR VA MEDICAL CENTER · PI ZIMMERS, TERESA A · 2020 to 2024
–Molecular Mechanisms of Muscle and Fat Wasting in Pancreatic Cancer CachexiaI01BX004177 · VA · RLR VA MEDICAL CENTER · PI ZIMMERS, TERESA A · 2018 to 2021
–BLRD VA I01 BX004177CSRD VA I01 CX002046NCI NIH HHS F31 CA254328NCI NIH HHS P01 CA097189NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA208253NCI NIH HHS T32 CA193201NIDDK NIH HHS P30 DK123704NIGMS NIH HHS P20 GM130457NIGMS NIH HHS R25 GM113278NIH HHS K01 OD026527
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma, which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types within the PDAC stroma and have context-dependent regulation of tumor progression in the tumor microenvironment (TME). Therefore, understanding tumor-promoting pathways in CAFs is essential for developing better stromal targeting therapies. Here, we show that disruption of the STAT3 signaling axis via genetic ablation of
Indexed as
Carcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorFibroblastsMiceTumor Microenvironment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.