Evidence map›Paper›PMID 35803696›Full record

Trial reportJournal of immunology (Baltimore, Md. : 1950)2022

Th2-Biased Transcriptional Profile Predicts HIV Envelope-Specific Polyfunctional CD4

Kristen W Cohen, Yuan Tian, Casey Thayer, Aaron Seese, Robert Amezquita, M Juliana McElrath, Stephen C De Rosa, Raphael Gottardo

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Tailoring TeLife · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Kristen W CohenVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID 0000-0002-8901-9941
Yuan TianVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Casey ThayerVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID 0000-0002-3971-1323
Aaron SeeseVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Robert AmezquitaBiostatistics, Bioinformatics and Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; and.
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID 0000-0003-2276-7117
Stephen C De RosaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Raphael GottardoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; raphael.gottardo@chuv.ch.ORCID 0000-0002-3867-0232
Infectious Disease Research Institute · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZA

Funding

LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
Systems Biology CoreU19AI128914 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Margaret Juliana McElrath, KENNETH D STUART · 2017 to 2026
$29.5M
Immune signatures of protection induced by whole parasite malaria vaccinesU19AI089986 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI MCELRATH, MARGARET JULIANA, STUART, KENNETH D · 2010 to 2015
$2.3M
NIAID NIH HHS U19 AI089986NIAID NIH HHS U19 AI128914NIAID NIH HHS UM1 AI068618
6 · The paper itself

Abstract

Ag-specific T cells play a critical role in responding to viral infections. In the RV144 HIV vaccine clinical trial, a rare subset of HIV-specific polyfunctional CD4

Indexed as

AIDS VaccinesHIV-1HIV InfectionsCD4-Positive T-LymphocytesCytokinesHIV AntibodiesHumansT-LymphocytesAIDS VaccinesCytokinesHIV Antibodies

Identifiers

PMID35803696
PMCPMC9476163
OpenAlexW4284987938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.