Evidence map›Paper›PMID 35803695›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and

Sambasivan Venkatasubramanian, Robyn Pryor, Courtney Plumlee, Sarah B Cohen, Jason D Simmons, Alexander J Warr, Andrew D Graustein, Aparajita Saha, Thomas R Hawn, Kevin B Urdahl and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sambasivan VenkatasubramanianUniversity of Washington, Seattle, WA.
Robyn PryorUniversity of Washington, Seattle, WA.
Courtney PlumleeSeattle Children's Research Institute, Seattle, WA.ORCID 0000-0001-7142-4394
Sarah B CohenSeattle Children's Research Institute, Seattle, WA.ORCID 0000-0002-7850-3498
Jason D SimmonsUniversity of Washington, Seattle, WA.ORCID 0000-0002-7669-2803
Alexander J WarrUniversity of Washington, Seattle, WA.
Andrew D GrausteinUniversity of Washington, Seattle, WA.
Aparajita SahaUniversity of Washington, Seattle, WA.ORCID 0000-0002-5014-6687
Thomas R HawnUniversity of Washington, Seattle, WA.
Kevin B UrdahlSeattle Children's Research Institute, Seattle, WA.
Javeed A ShahUniversity of Washington, Seattle, WA; jashah@uw.edu.ORCID 0000-0002-2997-7988
University of Washington · US

Funding

Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SASSETTI, CHRISTOPHER M · 2017 to 2021
$11.2M
TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis SusceptibilityR01AI136921 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2018 to 2022
$2.5M
Macrophages and Resistance to Mycobacterium Tuberculosis Infection in HumansK08AI143926 · NIAID · UNIVERSITY OF WASHINGTON · PI SIMMONS, JASON · 2019 to 2023
$951k
TOLLIP and Tuberculosis ImmunopathogenesisK08AI102971 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2013 to 2016
$708k
Acquisition of BD FACSymphony A3 Lite Flow CytometerS10OD024979 · OD · UNIVERSITY OF WASHINGTON · PI BLACK, MICHELE C · 2020 to 2020
$344k
NIAID NIH HHS K08 AI102971NIAID NIH HHS K08 AI143926NIAID NIH HHS P01 AI132130NIAID NIH HHS R01 AI136921NIH HHS S10 OD024979
6 · The paper itself

Abstract

TOLLIP is a central regulator of multiple innate immune signaling pathways, including TLR2, TLR4, IL-1R, and STING. Human TOLLIP deficiency, regulated by single-nucleotide polymorphism rs5743854, is associated with increased tuberculosis risk and diminished frequency of bacillus Calmette-Guérin vaccine-specific CD4

Indexed as

Mycobacterium tuberculosisTuberculosisAnimalsBCG VaccineCD40 AntigensDendritic CellsHumansInterleukin-12Intracellular Signaling Peptides and ProteinsLipopolysaccharidesMiceMice, Inbred C57BLBCG VaccineCD40 AntigensInterleukin-12Intracellular Signaling Peptides and ProteinsLipopolysaccharidesTOLLIP protein, humanTollip protein, mouse

Identifiers

PMID35803695
PMCPMC9339496
OpenAlexW4284992064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.