ArticleThe British journal of ophthalmology2023
Factors associated with choroidal microvascular dropout change.
Article in The British journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Progression in Preperimetric Glaucoma Eyes With and Without Microvasculature Dropout.American journal of ophthalmology · 2026Article
- Prediction of Visual Field Progression in Myopic Normal Tension Glaucoma Using a Nomogram-Based Model.Journal of clinical medicine · 2026Article
- Lights and Shadows on Artificial Intelligence in Glaucoma: Transforming Screening, Monitoring, and Prognosis.Journal of clinical medicine · 2025Review
- Comparative features of superior versus inferior hemisphere microvasculature dropout in open-angle glaucoma.Japanese journal of ophthalmology · 2024Article
- Clinical characteristics of open-angle glaucoma progression with peripapillary microvasculature dropout in different locations.Eye (London, England) · 2024Article
- Intraocular pressure increases the rate of macular vessel density loss in glaucoma.The British journal of ophthalmology · 2024Observational
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND/
aimsTo investigate the factors associated with choroidal microvasculature drop-out (MvD) enlargement detected by optical coherence tomography angiography (OCT-A) in glaucomatous eyes.
methodsNinety-one eyes of 68 primary open-angle glaucoma patients were enrolled. Only eyes with a minimum of four good quality OCT-A and OCT scans of the optic nerve head acquired at least and with a minimum of 2 years follow-up were included. Area and angular circumference of MvD were analysed on en face images. Univariable and multivariable mixed effects models were constructed to identify the factors contributing to MvD area and angular circumference change over time.
resultsPeripapillary MvD was detected in 53 (58.2%) eyes at baseline and in an additional 17 (18.6%) eyes during follow-up, whereas MvD was not detected in 21 (23.0 %) eyes during the entire follow-up period. In multivariable analysis, worse baseline visual field (VF) mean deviation (MD) (ß=0.27, 95% CI 0.10 to 0.44, p=0.002), greater intraocular pressure (IOP) fluctuations (ß=0.86, 95% CI 0.24 to 1.48, p=0.007), higher peak IOP (ß=0.17, 95% CI -0.01 to 0.35, p=0.067) and greater number of IOP lowering medications (ß=1.36, 95% CI 0.67 to 2.05, p<0.001) were associated with faster MvD area enlargement. Worse baseline VF MD and greater IOP fluctuation were also associated with significantly faster MvD circumferential enlargement in multivariable models.
conclusionGreater IOP fluctuation, higher peak IOP, worse baseline VF MD and greater number of glaucoma medications were significantly associated with MvD enlargement in glaucomatous eyes. The identification of factors associated with MvD enlargement may improve our understanding of the role of choroidal vasculature in glaucoma.
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