Evidence map›Paper›PMID 35803588›Full record

ReviewAnnual review of neuroscience2022

The Cerebellar Cortex.

Court Hull, Wade G Regehr

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
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  6. Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  12. Strategies to Decipher Neuron Identity from Extracellular Recordings in Behaving Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Court HullDepartment of Neurobiology, Duke University School of Medicine, Durham, North Carolina, USA; email: hull@neuro.duke.edu.
Wade G RegehrDepartment of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA; email: wade_regehr@hms.harvard.edu.

Funding

Mechanisms and Functions of Synapses and CircuitsR35NS097284 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2017 to 2024
$7.5M
Canonical computations for motor learning by the cerebellar cortex micro-circuitR01NS112917 · NINDS · DUKE UNIVERSITY · PI LISBERGER, STEPHEN G, MEDINA, JAVIER F · 2019 to 2023
$6.4M
Role of ASTN2 in Cerebellar Circuit Function and ASD-related BehaviorsR01NS116089 · NINDS · ROCKEFELLER UNIVERSITY · PI HATTEN, MARY ELIZABETH, HULL, COURT A · 2021 to 2025
$3.1M
A novel output pathway from the cerebellum for regulation of diverse non-motor behaviorsR01MH122570 · NIMH · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2020 to 2024
$2.9M
Neuromodulatory Control of Cerebellar Synaptic Processing and Sensory InputR01NS096289 · NINDS · DUKE UNIVERSITY · PI HULL, COURT A · 2016 to 2020
$1.7M
NIMH NIH HHS R01 MH122570NINDS NIH HHS R01 NS096289NINDS NIH HHS R01 NS112917NINDS NIH HHS R01 NS116089NINDS NIH HHS R35 NS097284
6 · The paper itself

Abstract

The cerebellar cortex is an important system for relating neural circuits and learning. Its promise reflects the longstanding idea that it contains simple, repeated circuit modules with only a few cell types and a single plasticity mechanism that mediates learning according to classical Marr-Albus models. However, emerging data have revealed surprising diversity in neuron types, synaptic connections, and plasticity mechanisms, both locally and regionally within the cerebellar cortex. In light of these findings, it is not surprising that attempts to generate a holistic model of cerebellar learning across different behaviors have not been successful. While the cerebellum remains an ideal system for linking neuronal function with behavior, it is necessary to update the cerebellar circuit framework to achieve its great promise. In this review, we highlight recent advances in our understanding of cerebellar-cortical cell types, synaptic connections, signaling mechanisms, and forms of plasticity that enrich cerebellar processing.

Indexed as

Neuronal PlasticityPurkinje CellsCerebellar CortexCerebellumLearningcerebellar circuitcerebellar interneuronsclimbing fiberephaptic signalingmotor learningPurkinje cell

Identifiers

PMID35803588
PMCPMC10268027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.