Evidence map›Paper›PMID 35803552›Full record

Trial reportJournal of vascular and interventional radiology : JVIR2022

Predictors of Clinical Outcomes of Pharmacomechanical Catheter-Directed Thrombolysis for Acute Iliofemoral Deep Vein Thrombosis: Analysis of a Multicenter Randomized Trial.

Siddhant Thukral, Amber Salter, Samantha Lancia, Susan R Kahn, Suresh Vedantham

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of vascular and interventional radiology : JVIR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Prevention of the Postthrombotic Syndrome: Where Do We Stand?Seminars in interventional radiology · 2025
    Review
  3. Review
  4. The role and principles of stenting in acute iliofemoral venous thrombosis.Journal of vascular surgery. Venous and lymphatic disorders · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Siddhant ThukralDepartment of Radiology, Duke University Medical Center, Durham, North Carolina.
Amber SalterDivision of Biostatistics, Washington University in St. Louis, St. Louis, Missouri.
Samantha LanciaDivision of Biostatistics, Washington University in St. Louis, St. Louis, Missouri.
Susan R KahnDepartment of Medicine, McGill University, Division of Internal Medicine & Center for Clinical Epidemiology, Jewish General Hospital, Montreal, Québec, Canada.
Suresh VedanthamMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, Missouri. Electronic address: vedanthams@wustl.edu.
Washington University in St. Louis · USDuke Medical Center · USJewish General Hospital · CA

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Translational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1TR002344 · NCATS · WASHINGTON UNIVERSITY · PI Jay F. Piccirillo · 2017 to 2026
$8.5M
1/2 CATHETER-DIRECTED THERAPY FOR CHRONIC DVT (C-TRACT TRIAL)UH3HL138325 · NHLBI · WASHINGTON UNIVERSITY · PI VEDANTHAM, SURESH · 2018 to 2023
$8.1M
PHARMACOMECHANICAL CATHETER-DIRECTED THROMBOLYSIS FOR ACUTE DVT - ATTRACT TRIALU01HL088476 · NHLBI · WASHINGTON UNIVERSITY · PI VEDANTHAM, SURESH · 2008 to 2013
$7.2M
Data Coordinating Centre for ATTRACT TrialU01HL088118 · NHLBI · MCMASTER UNIVERSITY · PI KEARON, CLIVE · 2008 to 2012
$2.9M
NCATS NIH HHS TL1 TR002344NCATS NIH HHS UL1 TR002345NHLBI NIH HHS U01 HL088118NHLBI NIH HHS U01 HL088476NHLBI NIH HHS U54 HL112303NHLBI NIH HHS UH3 HL138325
6 · The paper itself

Abstract

purposeTo identify the baseline patient characteristics that predict who will benefit from pharmacomechanical catheter-directed thrombolysis (PCDT) of acute iliofemoral deep vein thrombosis (DVT). MATERIALS AND

methodsIn the Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) multicenter randomized trial, 381 patients with acute iliofemoral DVT underwent PCDT and anticoagulation or anticoagulation alone. The correlations between baseline factors and venous clinical outcomes were evaluated over 24 months using post hoc regression analyses. Interaction terms were examined to evaluate for differential effects by treatment arm.

resultsPatients with clinically severe DVT (higher baseline Villalta score) experienced greater effects of PCDT in improving 24-month venous outcomes, including moderate or severe postthrombotic syndrome (PTS) (odds ratios [ORs] and 95% confidence intervals [CIs] per unit increase in the baseline Villalta scores were as follows: for PCDT, OR, 1.08 [95% CI, 1.01-1.15]; for control, OR, 1.20 [95% CI, 1.12-1.29]; P

conclusionsIn patients with acute iliofemoral DVT, greater presenting clinical severity (higher baseline Villalta score) and a history of previous DVT predict enhanced benefits from PCDT.

Indexed as

Postthrombotic SyndromeVenous ThrombosisAnticoagulantsCathetersFibrinolytic AgentsHumansIliac VeinPopliteal VeinQuality of LifeThrombolytic TherapyTreatment OutcomeAnticoagulantsFibrinolytic Agents

Identifiers

PMID35803552
PMCPMC11537305
OpenAlexW4284701613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.