ArticleCurrent biology : CB2022
Medial prefrontal cortex lesions disrupt prepotent action selection signals in dorsomedial striatum.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.Behavioral neuroscience · 2026Article
- Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Healthy aging in rats is associated with a decline in the ability to inhibit maladaptive responses, but not in measures of self-control by delayed gratification.Frontiers in aging neuroscience · 2025Article
- Anterior cingulate cortex lesions impair multiple facets of task engagement not mediated by dorsomedial striatum neuron firing.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Distinct Action Signals by Subregions in the Nucleus Accumbens during STOP-Change Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Analysis of the status quo and clinical influencing factors of the social cognitive impairment in deficit schizophrenia.Frontiers in psychiatry · 2024Article
- A study on the exploration of mild cognitive impairment in Parkinson's disease based on decision-making cognitive computing.Frontiers in neuroscience · 2024Article
- Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.Frontiers in aging neuroscience · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
The ability to inhibit or adapt unwanted actions or movements is a critical feature of almost all forms of behavior. Many have attributed this ability to frontal brain areas such as the anterior cingulate cortex (ACC) and the medial prefrontal cortex (mPFC), but the exact contribution of each brain region is often debated because their functions are not examined in animals performing the same task. Recently, we have shown that ACC signals a need for cognitive control and is crucial for the adaptation of action selection signals in dorsomedial striatum (DMS) in rats performing a stop-change task. Here, we show that unlike ACC, the prelimbic region of mPFC does not disrupt the inhibition or adaption of an action plan at either the level of behavior or downstream firing in DMS. Instead, lesions to mPFC correlate with changes in DMS signals involved in action initiation and disrupt performance on GO trials while improving performance on STOP trials.
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