Evidence map›Paper›PMID 35802702›Full record

ArticleJournal of medicinal chemistry2022

Design, Synthesis, and Characterization of [

Gengyang Yuan, Maeva Dhaynaut, Nicolas J Guehl, Sepideh Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M Iyengar, Manish Kumar Jain, Julie E Pickett, Hye Jin Kang and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Distribution of [Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  3. Synthesis and Characterization of 5-(2-Fluoro-4-[Journal of medicinal chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Gengyang YuanGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.ORCID 0000-0003-4817-0052
Maeva DhaynautGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.
Nicolas J GuehlGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.ORCID 0000-0001-6876-8292
Sepideh AfsharGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.
Dalena HuynhGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.
Sung-Hyun MoonGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.
Suhasini M IyengarDepartment of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.ORCID 0000-0002-1304-3021
Manish Kumar JainDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0001-8173-3326
Julie E PickettDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-9535-8528
Hye Jin KangDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States.
Mary Jo OndrechenDepartment of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States.ORCID 0000-0003-2456-4313
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.
Anna-Liisa BrownellGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-3814-868X
Harvard University · USUniversity of North Carolina at Chapel Hill · USNortheastern University · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Positive Allosteric Modulators as PET Imaging Ligans for mGluR4R01NS100164 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2020
$3.7M
Designing group specific PET ligands for mGluR2R01EB021708 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2019
$2.2M
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
F-18 SynthesizerS10RR023452 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2007 to 2007
$500k
Gamma counter and continuous blood sampler for quantitative PET imagingS10OD018035 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES, NORMANDIN, MARC DAVID · 2014 to 2014
$144k
NCRR NIH HHS S10 RR023452NIBIB NIH HHS P41 EB022544NIBIB NIH HHS R01 EB021708NIH HHS S10 OD018035NIH HHS S10 OD025234NINDS NIH HHS R01 NS100164
6 · The paper itself

Abstract

An array of triazolopyridines based on JNJ-46356479 (

Indexed as

Receptors, Metabotropic GlutamateAnimalsBrainLigandsPositron-Emission TomographyRadiopharmaceuticalsRatsRats, Sprague-DawleyLigandsmetabotropic glutamate receptor 2RadiopharmaceuticalsReceptors, Metabotropic Glutamate

Identifiers

PMID35802702
PMCPMC9434700
OpenAlexW4284977827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.