Evidence map›Paper›PMID 35802680›Full record

ArticlePloS one2022

Assessment of left atrial fibrosis progression in canines following rapid ventricular pacing using 3D late gadolinium enhanced CMR images.

Nadia A Farrag, Rebecca E Thornhill, Frank S Prato, Allan C Skanes, Rebecca Sullivan, David Sebben, John Butler, Jane Sykes, Benjamin Wilk, Eranga Ukwatta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Nadia A FarragDepartment of Systems & Computer Engineering, Carleton University, Ottawa, ON, Canada.ORCID 0000-0001-8801-7365
Rebecca E ThornhillDepartment of Systems & Computer Engineering, Carleton University, Ottawa, ON, Canada.ORCID 0000-0001-5308-5106
Frank S PratoDepartment of Medical Imaging and Medical Biophysics, University of Western Ontario, London, ON, Canada.
Allan C SkanesDepartment of Medicine, University of Western Ontario, London, ON, Canada.
Rebecca SullivanDepartment of Medical Imaging and Medical Biophysics, University of Western Ontario, London, ON, Canada.
David SebbenSchool of Engineering, University of Guelph, Guelph, ON, Canada.
John ButlerLawson Health Research Institute, London, ON, Canada.
Jane SykesLawson Health Research Institute, London, ON, Canada.
Benjamin WilkDepartment of Medical Imaging and Medical Biophysics, University of Western Ontario, London, ON, Canada.
Eranga UkwattaSchool of Engineering, University of Guelph, Guelph, ON, Canada.
Western University · CACarleton University · CALawson Health Research Institute · CAUniversity of Guelph · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is associated with extracellular matrix (ECM) remodelling and often coexists with myocardial fibrosis (MF); however, the causality of these conditions is not well established.

objectiveWe aim to corroborate AF to MF causality by quantifying left atrial (LA) fibrosis in cardiac magnetic resonance (CMR) images after persistent rapid ventricular pacing and subsequent AF using a canine model and histopathological validation.

methodsTwelve canines (9 experimental, 3 control) underwent baseline 3D LGE-CMR imaging at 3T followed by insertion of a pacing device and 5 weeks of rapid ventricular pacing to induce AF (experimental) or no pacing (control). Following the 5 weeks, pacing devices were removed to permit CMR imaging followed by excision of the hearts and histopathological imaging. LA myocardial segmentation was performed manually at baseline and post-pacing to permit volumetric %MF quantification using the image intensity ratio (IIR) technique, wherein fibrosis was defined as pixels > mean LA myocardium intensity + 2SD.

resultsVolumetric %MF increased by an average of 2.11 ± 0.88% post-pacing in 7 of 9 experimental dogs. While there was a significant difference between paired %MF measurements from baseline to post-pacing in experimental dogs (P = 0.019), there was no significant change in control dogs (P = 0.019 and P = 0.5, Wilcoxon signed rank tests). The median %MF for paced animals was significantly greater than that of non-paced dogs at the 5-week post-insertion time point (P = 0.009, Mann Whitney U test). Histopathological imaging yielded an average %MF of 19.42 ± 4.80% (mean ± SD) for paced dogs compared to 1.85% in one control dog.

conclusionPersistent rapid ventricular pacing and subsequent AF leads to an increase in LA fibrosis volumes measured by the IIR technique; however, quantification is limited by inherent image acquisition parameters and observer variability.

Indexed as

Atrial FibrillationCardiomyopathiesAnimalsContrast MediaDogsFibrosisGadoliniumHeart AtriaMagnetic Resonance ImagingContrast MediaGadolinium

Identifiers

PMID35802680
PMCPMC9269919
OpenAlexW4284974379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.