ArticlePloS one2022
Characterization of regional variation of bone mineral density in the geriatric human cervical spine by quantitative computed tomography.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Characterizing the Baseline Regional Biphasic Mechanical Properties of Cervical Intervertebral Discs.Annals of biomedical engineering · 2025Article
- Development of a spinopelvic complex finite element model for quantitative analysis of the biomechanical response of patients with degenerative spondylolisthesis.Medical & biological engineering & computing · 2025Article
- Article
- A comparative study of the effect of facet tropism on the index-level kinematics and biomechanics after artificial cervical disc replacement (ACDR) with Prestige LP, Prodisc-C vivo, and Mobi-C: a finite element study.Journal of orthopaedic surgery and research · 2024Article
- Distribution characteristics of stress on the vertebrae following different ranges of excision during Modified Anterior Cervical Discectomy and Fusion: A correlation study based on finite element analysis.BMC musculoskeletal disorders · 2024Article
- Biomechanical study between percutaneous vertebroplasty combined with cement pedicle plasty improves vertebral biomechanical stability: A finite element analysis.BMC musculoskeletal disorders · 2024Article
- Finite element modeling and analysis of effect of preexisting cervical degenerative disease on the spinal cord during flexion and extension.Medical & biological engineering & computing · 2024Article
- Finite element analysis of different pedicle screw internal fixations for first lumbar vertebral fracture in different sports conditions.The Journal of international medical research · 2024Article
- The impact of disc degeneration on the dynamic characteristics of the lumbar spine: a finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study.Frontiers in bioengineering and biotechnology · 2024Article
- Biomechanical analysis of the tandem spinal external fixation in a multiple-level noncontiguous lumbar fractures model: a finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Analyzing isolated degeneration of lumbar facet joints: implications for degenerative instability and lumbar biomechanics using finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Segment selection for fusion and artificial disc replacement in the hybrid surgical treatment of noncontiguous cervical spondylosis: a finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Biomechanical assessment of anterior plate system, bilateral pedicle screw and transdiscal screw system for high-grade spondylolisthesis: a finite element study.Frontiers in bioengineering and biotechnology · 2024Article
- Biomechanical analysis of sandwich vertebrae in osteoporotic patients: finite element analysis.Frontiers in endocrinology · 2023Article
- Stability simulation analysis of targeted puncture in L4/5 intervertebral space for PELD surgery.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOdontoid process fractures are among the most common in elderly cervical spines. Their treatment often requires fixation, which may include use of implants anteriorly or posteriorly. Bone density can significantly affect the outcomes of these procedures. Currently, little is known about bone mineral density (BMD) distributions within cervical spine in elderly. This study documented BMD distribution across various anatomical regions of elderly cervical vertebrae. METHODS AND
findingsTwenty-three human cadaveric C1-C5 spine segments (14 males and 9 female, 74±9.3 y.o.) were imaged via quantitative CT-scan. Using an established experimental protocol, the three-dimensional shapes of the vertebrae were reconstructed from CT images and partitioned in bone regions (4 regions for C1, 14 regions for C2 and 12 regions for C3-5). The BMD was calculated from the Hounsfield units via calibration phantom. For each vertebral level, effects of gender and anatomical bone region on BMD distribution were investigated via pertinent statistical tools. Data trends suggested that BMD was higher in female vertebrae when compared to male ones. In C1, the highest BMD was found in the posterior portion of the bone. In C2, BMD at the dens was the highest, followed by lamina and spinous process, and the posterior aspect of the vertebral body. In C3-5, lateral masses, lamina, and spinous processes were characterized by the largest values of BMD, followed by the posterior vertebral body.
conclusionsThe higher BMD values characterizing the posterior aspects of vertebrae suggest that, in the elderly, posterior surgical approaches may offer a better fixation quality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.