Evidence map›Paper›PMID 35802342›Full record

ArticleInfection2023

First Italian report of a liver abscess and metastatic endogenous endophthalmitis caused by ST-23 hypervirulent Klebsiella pneumoniae in an immunocompetent individual.

Maria A De Francesco, Giorgio Tiecco, Erika Scaltriti, Giorgio Piccinelli, Silvia Corbellini, Francesca Gurrieri, Verena Crosato, Giovanni Moioli, Valentina Marchese, Emanuele Focà and 3 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2024
    Pooled it
  2. HypervirulentInternational journal of surgery case reports · 2026
    Article
  3. Article
  4. Co-evolution of resistance and virulence inFrontiers in cellular and infection microbiology · 2026
    Review
  5. Review
  6. Article
  7. Molecular analysis ofOpen veterinary journal · 2025
    Article
  8. Article
  9. Article
  10. HypervirulentPathogens & immunity · 2024
    Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Maria A De Francesco *Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 125123, Brescia, Italy. maria.defrancesco@unibs.it.ORCID http://orcid.org/0000-0003-2221-6286
Giorgio Tiecco *Division of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Erika ScaltritiInstitute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 125123, Brescia, Italy.
Giorgio PiccinelliInstitute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 125123, Brescia, Italy.
Silvia CorbelliniInstitute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 125123, Brescia, Italy.
Francesca GurrieriInstitute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 125123, Brescia, Italy.
Verena CrosatoDivision of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Giovanni MoioliDivision of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Valentina MarcheseDivision of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Emanuele FocàDivision of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Davide A BertelliDivision of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Francesco CastelliDivision of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili, Brescia, Italy.
Arnaldo CarusoInstitute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-ASST Spedali Civili, P. Le Spedali Civili, 1, 125123, Brescia, Italy.
University of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKlebsiella pneumoniae is a common species in the gut of mammals and is widely distributed in the environment. However, the environmental source of hvKp that precedes gut colonization is unclear, but once that it reaches the gut there is a possible generalized spread y fecal-oral transmission especially in endemic areas. Liver abscess might develop when the bacteria, using its virulence factors, cross the intestinal barrier and invade the liver by the portal circulation. This syndrome, prevalent mostly in Asian countries, is increasingly reported in Western Countries and leaves open questions about the source of infection. CASE: Here we describe for the first time in Italy, a case of pyogenic liver abscess caused by a hypervirulent Klebsiella pneumoniae (HvKp) complicated by endophthalmitis and other metastatic infections in lung and prostate in an immunocompetent Chinese healthy individual with no recent travel in Asia.

conclusionThis case underlines the need for increased awareness of hypervirulent K. pneumoniae, even in settings where it occurs infrequently and where there are not evident epidemiological links.

Indexed as

EndophthalmitisKlebsiella InfectionsLiver AbscessAnimalsHumansKlebsiella pneumoniaeMaleMammalsVirulenceAbscessHvKpInvasiveLiverWGS

Identifiers

PMID35802342
PMCPMC9879799
OpenAlexW4284880371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.