Evidence map›Paper›PMID 35802312›Full record

ArticleSleep & breathing = Schlaf & Atmung2023

Retinal abnormalities, although relatively common in sleep clinic patients referred for polysomnography, are largely unrelated to sleep-disordered breathing.

Terence C Amis, Rita Perri, Sharon Lee, Meredith Wickens, Gerald Liew, Paul Mitchell, Kristina Kairaitis, John R Wheatley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Terence C AmisLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia. terry.amis@sydney.edu.au.
Rita PerriLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
Sharon LeeLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
Meredith WickensLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
Gerald LiewWestmead Clinical School, University of Sydney, Westmead, NSW, Australia.
Paul MitchellWestmead Clinical School, University of Sydney, Westmead, NSW, Australia.
Kristina KairaitisLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
John R WheatleyLudwig Engel Centre for Respiratory Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
Westmead Institute for Medical Research · AUWestmead Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesThere has been long-standing interest in potential links between obstructive sleep apnea (OSA) and eye disease. This study used retinal photography to identify undiagnosed retinal abnormalities in a cohort of sleep clinic patients referred for polysomnography (PSG) and then determined associations with PSG-quantified sleep-disordered breathing (SDB) severity.

methodsRetinal photographs (n = 396 patients) were taken of each eye prior to polysomnography and graded according to validated, standardized, grading scales. SDB was quantified via in-laboratory polysomnography (PSG; n = 385) using standard metrics. A questionnaire (n = 259) documented patient-identified pre-existing eye disease. Within-group prevalence rates were calculated on a per patient basis. Data were analyzed using multivariate logistic regression models to determine independent predictors for retinal abnormalities. P < 0.05 was considered significant.

resultsMain findings were (1) 76% of patients reported no pre-existing "eye problems"; (2) however, 93% of patients had at least one undiagnosed retinal photograph-identified abnormality; (3) most common abnormalities were drusen (72%) and peripapillary atrophy (PPA; 47%); (4) age was the most common risk factor; (5) diabetes history was an expected risk factor for retinopathy; (6) patients with very severe levels of SDB (apnea hypopnea index ≥ 50 events/h) were nearly three times more likely to have PPA.

conclusionRetinal photography in sleep clinic settings will likely detect a range of undiagnosed retinal abnormalities, most related to patient demographics and comorbidities and, except for PPA, not associated with SDB. PPA may be indicative of glaucoma, and any association with severe SDB should be confirmed in larger prospective studies.

Indexed as

Sleep Apnea, ObstructiveSleep Apnea SyndromesHumansPolysomnographyProspective StudiesSleepAge-related macular degenerationObstructive sleep apneaPeripapillary atrophyRetinal photographySleep-disordered breathing

Identifiers

PMID35802312
PMCPMC10227130
OpenAlexW4284894136

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.