Evidence map›Paper›PMID 35802244›Full record

ArticleHead and neck pathology2022

Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component.

Pooja Bhakta, Ayman Youssef, Lindsay Bigham, Jayati Mallick, Peeyush Bhargava, Faisal Rawas, Dylan Weaver, Zachary E Hunzeker, Jianli Dong, Maurice Willis and 4 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Pooja Bhakta *Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Ayman Youssef *Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Lindsay Bigham *Department of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jayati MallickDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Peeyush BhargavaDepartment of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
Faisal RawasDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Dylan WeaverDepartment of Radiology, University of Texas Medical Branch, Galveston, TX, USA.
Zachary E HunzekerDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Jianli DongDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Maurice WillisDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Suimin QiuDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Ranjana NawgiriDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Chukwuemeka-Chi C IguhDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA.
Kirill A LyapichevDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, 77555, USA. Kilyapic@utmb.edu.ORCID http://orcid.org/0000-0001-9983-9735
The University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary bone lymphoma is a rare type of lymphoid neoplasm with favorable prognosis, where Primary Non Hodgkin Lymphoma of bone (PB-NHL) is most common with the subtype. Amongst PB-NHL, diffuse large Bcell lymphoma represents the majority of cases. The mandible is a very uncommon site of involvement, presenting as a painful bone mass with high suspicion of osteomyelitis.

methodsWe report the case of a 45-year-old male with no significant past medical history who was admitted to the hospital with a large right jaw mass and pain after recent tooth removal. The original tissue biopsy was not diagnostic, and cultures were found to be negative for microorganisms. Due to enlargement of the mass, a fine needle aspiration (FNA) was done. At the time of rapid onsite evaluation of the FNA, atypical lymphoid cells were seen, and material was obtained for flow cytometry (FC) evaluation. This revealed an aberrant clonal B-cell population. The consequent immunohistochemical evaluation of original material supported the diagnosis of PB-NHL. After chemotherapy patient improved.

resultsAfter an extensive English language literature review, we identified and summarized the clinical presentations, diagnostic procedures, histopathologic features, treatment methods, and outcomes of forty-two cases of periodontal PB-NHL. Based on our findings, we propose a set of clinical features at initial presentation to increase the clinical suspicion of periodontal PB-NHL for practitioners.

conclusionBased on our institution's experience and the literature review conclusions, we propose the University of Texas Medical Branch diagnostic approach for PB-NHL and suggest that FNA and FC should be utilized as the essential diagnostic component. The fast and efficient diagnosis of PB-NHL can facilitate the correct treatment and sufficiently improve patient care.

Indexed as

LymphomaLymphoma, Non-HodgkinFlow CytometryHumansMiddle AgedExcisional biopsyFibrosisFine-needle aspirationFlow cytometryImmunohistochemistryMandibleNon-Hodgkin lymphomaOsteolytic lesionPrimary bone lymphomaRituximab

Identifiers

PMID35802244
PMCPMC9729681
OpenAlexW4284879442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.