Evidence map›Paper›PMID 35802208›Full record

ArticleEuropean journal of pediatrics2022

Outcomes in neonates born to mothers with COVID-19 during the second wave in India.

Sushma Malik, Dipty Jain, Chandrakant M Bokade, Shakira Savaskar, Laxmikant S Deshmukh, Poonam Wade, Abhishek D Madhura, Milind Suryawanshi, Sachin T Bandichhode, Sachin B Bodhgire and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Sushma Malik *Department of Paediartrics, Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.
Dipty Jain *Department of Paediartrics, Government Medical College, Nagpur, Maharashtra, India.
Chandrakant M Bokade *Department of Paediartrics, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.
Shakira Savaskar *Department of Paediartrics, Dr Vaishampayan Memorial Government Medical College, Solapur, Maharashtra, India.
Laxmikant S Deshmukh *Department of Paediatrics, Government Medical College, Aurangabad, Maharashtra, India.
Poonam WadeDepartment of Paediartrics, Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, Maharashtra, India.
Abhishek D MadhuraDepartment of Paediartrics, Government Medical College, Nagpur, Maharashtra, India.
Milind SuryawanshiDepartment of Paediartrics, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.
Sachin T BandichhodeDepartment of Paediartrics, Dr Vaishampayan Memorial Government Medical College, Solapur, Maharashtra, India.
Sachin B BodhgireDepartment of Paediatrics, Government Medical College, Aurangabad, Maharashtra, India.
Sarika ZalaClinical Research Lab, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, India.
Smita D MahaleEmeritus Scientist, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, India.
Deepak N ModiMolecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, India.
Rakesh WaghmareMedical Education and Drugs Department, Government of Maharashtra, Mumbai, India. rakeshbw0326@gmail.com.
Suchitra V SurveChild Health Research Department, ICMR-National Institute for Research in Reproductive and Child Health, Maharashtra, Parel, Mumbai, India. dr.suchi172@gmail.com.
Rahul K GajbhiyeClinical Research Lab, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, India. gajbhiyer@nirrch.res.in.ORCID http://orcid.org/0000-0003-3864-1818
National Institute for Research in Reproductive Health · INGovernment Medical College · INDr. V. M. Government Medical College · INGovernment Medical College · INTopiwala National Medical College & BYL Nair Charitable Hospital · INGovernment of Maharashtra · IN

Funding

Wellcome Trust
6 · The paper itself

Abstract

COVID-19 pandemic has affected all age groups globally including pregnant women and their neonates. The aim of the study was to understand outcomes in neonates of mothers with COVID-19 during the first and second waves of COVID-19 pandemic. A retrospective analysis of 2524 neonates born to SARS-CoV-2-infected mothers was conducted during the first wave (n = 1782) and second wave (n = 742) of the COVID-19 pandemic at five study sites of the PregCovid registry in Maharashtra, India. A significant difference was noted in preterm birth, which was higher in the second wave (15.0%, 111/742) compared to the first wave (7.8%, 139/1782) (P < 0.001). The proportion of neonates requiring NICU admission was significantly higher in the second wave (19.0%, 141/742) as compared to that in the first wave (14.8%, 264/1782) (P < 0.05). On comparing regional differences, significantly higher neonatal complications were reported from Mumbai metropolitan region (P < 0.05). During the second wave of COVID-19, birth asphyxia and prematurity were 3.8- and 2.1-fold higher respectively (P < 0.001). Neonatal resuscitation at birth was significantly higher in second wave (3.4%, 25/742 vs 1.8%, 32/1782) (P < 0.05). The prevalence of SARS-CoV-2 infection in neonates was comparable (4.2% vs 4.6%) with no significant difference between the two waves.

conclusionHigher incidence of adverse outcomes in neonates born to SARS-CoV-2-infected mothers in the second wave of COVID-19 as compared to the first wave.

trial registrationPregCovid study is registered with the Clinical Trial Registry of India (CTRI/2020/05/025423, Registered on 28/05/2020). WHAT IS KNOWN: • The second wave of COVID-19 was more lethal to pregnant women than the first wave. Newborns are at risk of developing complications. WHAT IS NEW: • Birth asphyxia, prematurity, and neonatal resuscitation at birth were significantly higher in the second wave as compared to those in the first wave of the COVID-19 pandemic in India.

Indexed as

COVID-19Infant, Newborn, DiseasesPregnancy Complications, InfectiousPremature BirthAsphyxiaFemaleHumansIndiaInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalMothersPandemicsPregnancyResuscitationRetrospective StudiesNeonatal complicationsNICUSARS-CoV-2Second wave

Identifiers

PMID35802208
PMCPMC9263042
OpenAlexW4284891367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.