Evidence map›Paper›PMID 35802201›Full record

ArticleJournal of neurology2022

Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry.

Felix Kohle, Marie Madlener, Emanuel Francesco Bruno, Gereon Rudolf Fink, Volker Limmroth, Lothar Burghaus, Michael Peter Malter

Abstract readMulticenter Study
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Felix Kohle *Department of Neurology, Faculty of Medicine, University of Cologne and University Hospital of Cologne, Kerpener Strasse, 62, 50937, Cologne, Germany. felix.kohle@uk-koeln.de.ORCID http://orcid.org/0000-0002-4429-0367
Marie Madlener *Department of Neurology, Faculty of Medicine, University of Cologne and University Hospital of Cologne, Kerpener Strasse, 62, 50937, Cologne, Germany.
Emanuel Francesco BrunoDepartment of Neurology and Palliative Medicine, Cologne City Hospitals, Cologne, Germany.
Gereon Rudolf FinkDepartment of Neurology, Faculty of Medicine, University of Cologne and University Hospital of Cologne, Kerpener Strasse, 62, 50937, Cologne, Germany.
Volker LimmrothDepartment of Neurology and Palliative Medicine, Cologne City Hospitals, Cologne, Germany.
Lothar BurghausDepartment of Neurology, Heilig Geist Krankenhaus, Cologne, Germany.
Michael Peter MalterDepartment of Neurology, Faculty of Medicine, University of Cologne and University Hospital of Cologne, Kerpener Strasse, 62, 50937, Cologne, Germany. michael.malter@uk-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe "coronavirus disease 2019" (COVID-19) pandemic, caused by the "severe-acute-respiratory-syndrome-coronavirus 2" (SARS-CoV-2), challenges healthcare systems worldwide and impacts not only COVID-19 patients but also other emergencies. To date, data are scarce on the extent to which the COVID-19 pandemic impacted status epilepticus (SE) and its treatment.

objectiveTo assess the influence of the COVID-19 pandemic on the incidence, management and outcome of SE patients. STUDY

designThis is a retrospective, multicentre trial, approved by the University of Cologne (21-1443-retro).

methodsAll SE patients from the urban area of Cologne transmitted to all acute neurological departments in Cologne between 03/2019 and 02/2021 were retrospectively analysed and assessed for patient characteristics, SE characteristics, management, and outcome in the first pandemic year compared to the last pre-pandemic year.

results157 pre-pandemic (03/2019-02/2020) and 171 pandemic (from 03/2020 to 02/2021) SE patients were included in the analyses. Acute SARS-CoV-2 infections were rarely detected. Patient characteristics, management, and outcome did not reveal significant groupwise differences. In contrast, regarding prehospital management, a prolonged patient transfer to the hospital and variations in SE aetiologies compared to the last pre-pandemic year were observed with less chronic vascular and more cryptogenic and anoxic SE cases. No infections with SARS-CoV-2 occurred during inpatient stays.

conclusionsSARS-CoV-2 infections did not directly affect SE patients, but the transfer of SE patients to emergency departments was delayed. Interestingly, SE aetiology rates shifted, which warrants further exploration. Fears of contracting an in-hospital SARS-CoV-2-infection were unfounded due to consequent containment measures.

Indexed as

COVID-19Status EpilepticusGermanyHumansPandemicsRegistriesRetrospective StudiesSARS-CoV-2COVID-19SARS-CoV-2SeizureStatus epilepticus

Identifiers

PMID35802201
PMCPMC9266085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.