Evidence map›Paper›PMID 35801956›Full record

ArticleHuman vaccines & immunotherapeutics2022

A novel SARS-CoV-2 subunit vaccine engineered on an immune-activating platform technology.

Edward J Quinlan, Richard Chubet, Peter Leonardi

Abstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Edward J QuinlanResearch and Development, OmniCyte LLC, Guilford, CT, USA.
Richard ChubetResearch and Development, OmniCyte LLC, Guilford, CT, USA.
Peter LeonardiResearch and Development, OmniCyte LLC, Guilford, CT, USA.ORCID 0000-0002-6084-3603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While there are several SARS-CoV-2 vaccines currently available, additional options must be provided that are safe, effective, and affordable for the entire global population. We have developed a novel immune activating platform technology that will fill this need. This recombinant platform protein is produced in insect cells using baculoviral expression technology similar to what is currently used for several other approved vaccines as well as employed by myriad GMP facilities globally. Thus, infrastructure exists for rapid scale up following initial optimizations. Here we report initial results for a SARS-CoV-2 vaccine (OMN008) based on our platform technology. Unadjuvanted OMN008 vaccination resulted in robust antigenicity and neutralization. Additionally, OMN008 vaccination induced a specific CD8

Indexed as

COVID-19COVID-19 VaccinesHumansRecombinant ProteinsSARS-CoV-2Spike Glycoprotein, CoronavirusVaccine DevelopmentVaccines, SubunitCOVID-19 VaccinesRecombinant ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, SubunitbaculovirusDC-SIGNdendritic cellSARS-CoV-2subunitT-Cellvaccine

Identifiers

PMID35801956
PMCPMC9721441

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.