Evidence map›Paper›PMID 35801847›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2022

Increased Colocalization and Interaction Between Decidual Protein Kinase A and Insulin-like Growth Factor-Binding Protein-1 in Intrauterine Growth Restriction.

Madhulika B Gupta, Kyle K Biggar, Cun Li, Peter W Nathanielsz, Thomas Jansson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Madhulika B GuptaDepartment of Biochemistry and Department of Pediatrics, University of Western Ontario, London, ON, Canada.
Kyle K BiggarInstitute of Biochemistry, Carleton University, Ottawa, ON, Canada.
Cun LiUniversity of Wyoming, Laramie, Wyoming.
Peter W NathanielszUniversity of Wyoming, Laramie, Wyoming.ORCID 0000-0003-0802-0084
Thomas JanssonSouthwest National Primate Research Center, San Antonio, Texas.
University of Wyoming · USCarleton University · CATexas Biomedical Research Institute · USWestern University · CA

Funding

PARTURITION AND FETAL PRIMATE HYPOTHALAMIC FUNCTIONP01HD021350 · NICHD · UNIVERSITY OF WYOMING · PI JANSSON, THOMAS · 1987 to 2018
$19.9M
Womb to Tomb: Developmental Programming and Aging Interactions in PrimatesU19AG057758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CLARKE, GEOFFREY DAVID, COX, LAURA A · 2018 to 2024
$13.2M
Decidual nutrient sensing and IGFBP-1 phosphorylation in placental insufficiencyR01HD089980 · NICHD · UNIVERSITY OF COLORADO DENVER · PI GUPTA, MADHULIKA, JANSSON, THOMAS · 2017 to 2021
$1.4M
IGFBP-1 hyperphosphorylation in IUGR: Role of mTOR and CK2R03HD078313 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUPTA, MADHULIKA, JANSSON, THOMAS · 2014 to 2015
$147k
NIA NIH HHS U19 AG057758NICHD NIH HHS P01 HD021350NICHD NIH HHS R01 HD089980NICHD NIH HHS R03 HD078313
6 · The paper itself

Abstract

Increased phosphorylation of decidual insulin-like growth factor-binding protein-1 (IGFBP-1) can contribute to intrauterine growth restriction (IUGR) by decreasing the bioavailability of insulin-like growth factor-1 (IGF-1). However, the molecular mechanisms regulating IGFBP-1 phosphorylation at the maternal-fetal interface are poorly understood. Protein kinase A (PKA) is required for normal decidualization. Consensus sequences for PKA are present in IGFBP-1. We hypothesized that the expression/interaction of PKA with decidual IGFBP-1 is increased in IUGR. Parallel reaction monitoring-mass spectrometry (PRM-MS) identified multiple PKA peptides (

Indexed as

Fetal Growth RetardationCyclic AMP-Dependent Protein KinasesDeciduaFemaleHumansHypoxiaInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor IPregnancyCyclic AMP-Dependent Protein KinasesIGFBP1 protein, humanInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Ifluorescent antibody techniquehumanshypoxiamass spectrometrymaternalnutrient reductionpapioplacentastromal cells

Identifiers

PMID35801847
PMCPMC9284236
OpenAlexW4284958882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.