ReviewDevelopmental medicine and child neurology2022
Emerging signs of autism spectrum disorder in infancy: Putative neural substrate.
Review in Developmental medicine and child neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Execution, imitation and observation of naturalistic actions in autistic children and adolescents: a systematic review of fMRI studies.Frontiers in human neuroscience · 2026Pooled it
- Changing subplate circuits: Early activity dependent circuit plasticity.Frontiers in cellular neuroscience · 2022Pooled it
- Interplay between motor stereotypies, emotional dysregulation, and sensory reactivity in adolescents and adults with autism spectrum disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- The association between motor coordination impairment and altered functional connectivity among autistic children.Frontiers in pediatrics · 2026Article
- Latent motor growth trajectories of term and preterm infants based on caregiver report.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- Article
- Mapping autism in Egypt: population-based insights into prevalence, risk determinants, and severity among children aged 1-12 years.Molecular autism · 2025Article
- Cognitive Brain Networks and Enlarged Perivascular Spaces: Implications for Symptom Severity and Support Needs in Children with Autism.Journal of clinical medicine · 2025Article
- Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.Scientific reports · 2025Observational
- HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members.Microorganisms · 2024Review
- Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development.Nature communications · 2024Article
- Cranio-Facial Characteristics in Autism Spectrum Disorder: A Scoping Review.Journal of clinical medicine · 2024Article
- Once upon a Time Oral Microbiota: A Cinderella or a Protagonist in Autism Spectrum Disorder?Metabolites · 2023Review
- Article
- Combination of machine learning-based bulk and single-cell genomics reveals necroptosis-related molecular subtypes and immunological features in autism spectrum disorder.Frontiers in immunology · 2023Article
- Emerging signs of autism spectrum disorder in infancy: Putative neural substrate.Developmental medicine and child neurology · 2022Review
- The developing brain: Challenges and opportunities to promote school readiness in young children at risk of neurodevelopmental disorders in low- and middle-income countries.Frontiers in pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is characterized by altered development of the social brain with prominent atypical features in the fronto-temporo-parietal cortex and cerebellum. Early signs of ASD emerge between 6 and 12 months: reduced social communication, slightly less advanced motor development, and repetitive behaviour. The fronto-temporo-parietal cortex and cerebellum play a prominent role in the development of social communication, whereas fronto-parietal-cerebellar networks are involved in the planning of movements, that is, movement selection. Atypical sensory responsivity, a core feature of ASD, may result in impaired development of social communication and motor skills and/or selection of atypical repetitive behaviour. In the first postnatal year, the brain areas involved are characterized by gradual dissolution of temporary structures: the fronto-temporo-parietal cortical subplate and cerebellar external granular layer. It is hypothesized that altered dissolution of the transient structures opens the window for the expression of early signs of ASD arising in the impaired developing permanent networks. WHAT THIS PAPER ADDS: The early social and motor signs of autism spectrum disorder emerge between the ages of 6 and 12 months. Altered dissolution of transient brain structures in the fronto-temporo-parietal cortex and cerebellum may underlie the emergence of these early signs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.