Evidence map›Paper›PMID 35801632›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2022

Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age.

Thomas J Sandora, David N Williams, Kaitlyn Daugherty, Christine Geer, Christine Cuddemi, Larry K Kociolek, Xinhua Chen, Hua Xu, Timothy J Savage, Alice Banz and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Microorganisms · 2024
    Article
  2. Article
  3. Article
  4. Clostridioides difficile Infections: Prevention and Treatment Strategies.Advances in experimental medicine and biology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Thomas J SandoraDivision of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1755-5881
David N WilliamsInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
Kaitlyn DaughertyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-3718-5585
Christine GeerInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
Christine CuddemiDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Larry K KociolekDivision of Infectious Diseases, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Xinhua ChenDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Hua XuDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Timothy J SavageDivision of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9528-7379
Alice BanzbioMerieux, Marcy L'Etoile, France.
Kevin W GareyDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
Anne J Gonzales-LunaDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0003-1906-359X
Ciarán P KellyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Nira R PollockDepartment of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-6396-2915
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · USUniversity of Houston · USbioMérieux (France) · FRNorthwestern University · US

Funding

Ultrasensitive C.difficile toxin measurement for diagnosis and outcome predictionR01AI116596 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLOCK, NIRA · 2016 to 2020
$4.1M
National Institute of Allergy and Infectious DiseasesNIAID NIH HHS R01 AI116596NIH HHS 5 R01 AI116596
6 · The paper itself

Abstract

In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.

Indexed as

Bacterial ToxinsClostridioides difficileClostridium InfectionsChildChild, PreschoolFecesHumansProspective StudiesBacterial ToxinsClostridioides difficilepediatrics

Identifiers

PMID35801632
PMCPMC9595052
OpenAlexW4284879700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.