Evidence map›Paper›PMID 35801556›Full record

ArticleHead & neck2022

Prognostic value of computed tomography scan detection of cartilage invasion in advanced laryngeal cancer treated with primary total laryngectomy.

Maxwell Y Lee, Jonathan Lee, Sarah Stock, Mario Belfiglio, Brian Matia, Shlomo Koyfman, Nikhil P Joshi, Brian B Burkey, Eric Lamarre, Brandon Prendes and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Maxwell Y LeeLerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0001-7226-4855
Jonathan LeeDepartment of Diagnostic Radiology, Cleveland Clinic, Cleveland, Ohio, USA.
Sarah StockDepartment of Diagnostic Radiology, Cleveland Clinic, Cleveland, Ohio, USA.
Mario BelfiglioLerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Brian MatiaCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Shlomo KoyfmanDepartment of Radiation Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, USA.
Nikhil P JoshiDepartment of Radiation Oncology, Rush University Medical Center, Chicago, Illinois, USA.
Brian B BurkeyCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Eric LamarreCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.ORCID 0000-0001-9384-8470
Brandon PrendesCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Joseph ScharpfCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Robert R LorenzCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Neil M WoodyDepartment of Radiation Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, USA.ORCID 0000-0003-4507-6167
David J AdelsteinDepartment of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, USA.
Jessica L GeigerDepartment of Hematology and Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, USA.
Deborah J ChuteDepartment of Pathology, Cleveland Clinic, Cleveland, Ohio, USA.
Jamie A KuCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · USRush University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe sought to determine whether detection of cartilage invasion (CI) by computed tomography predicts oncologic outcomes after primary total laryngectomy.

methodsRetrospective cohort study comparing oncologic outcomes between radiologic versus pathologic diagnosis.

resultsAssessment of clear CI versus gestalt CI resulted in 84% versus 48% specificity, 90.9% versus 80.3% positive predictive value (PPV), 60.6% versus 80.3% sensitivity, 44.7% versus 48% negative predictive value (NPV), respectively. Disease-free survival (DFS) was similar between cT4a and cT3/cT2 patients (p = 0.87). DFS trended towards superiority among pT3/pT2 versus pT4a patients (p = 0.18). DFS was similar among patients with CI on radiologist gestalt versus no CI (p = 0.94). Histologically confirmed CI was associated with a hazard ratio (HR) of 1.46 (p = 0.27), gestalt CI 1.13 (p = 0.70), and clear CI 1.61 (p = 0.10) for DFS.

conclusionGestalt determination of CI results in high sensitivity but low specificity, while clear determination of CI results in moderate sensitivity and high specificity.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsCartilageHumansLaryngectomyNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesTomography, X-Ray Computedcartilage invasioncomputed tomographyhead and neck cancerlaryngeal cancertotal laryngectomy

Identifiers

PMID35801556
PMCPMC9544100
OpenAlexW4284888913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.