Evidence map›Paper›PMID 35801415›Full record

Observational studyBiomolecules & biomedicine2023

Evaluation of qualitative and quantitative taste alterations in COVID-19.

Angela Pia Cazzolla, Roberto Lovero, Francesca Spirito, Michele Di Cosola, Luigi Santacroce, Eleonora Lo Muzio, Domenico Ciavarella, Mario Dioguardi, Vito Crincoli, Maria Pepe and 4 more

Open access · diamondAbstract readObservational Study
In one paragraph

Observational study in Biomolecules & biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Blood biomarkers for the prediction of idiopathic taste dysfunction: a case-control study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  4. Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Angela Pia CazzollaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy.
Roberto LoveroClinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy.
Francesca SpiritoDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy.
Michele Di CosolaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy.
Luigi SantacroceIonian Department (DJSGEM), Microbiology and Virology Lab, Università Degli Studi di Bari, Bari, Italy.
Eleonora Lo MuzioDepartment of Translational Medicine and for Romagna, School of Orthodontics, University of Ferrara, Ferrara, Italy.
Domenico CiavarellaDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy.
Mario DioguardiDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Bari, Italy.
Vito CrincoliDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, "Aldo Moro" University of Bari, Bari, Italy.
Maria PepeTransfusional Medicine Unit, University-Policlinico, Bari, Italy.
Lucia VarrasoClinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy.
Renato ContinoClinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy.
Francesca Di SerioClinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, Università degli Studi di Foggia, Foggia, Italy; Consorzio Interuniversitario Nazionale per la Bio-Oncologia (C.I.N.B.O), Chieti, Italy.
University of Foggia · ITOspedale Pediatrico Giovanni XXIII · ITUniversity of Bari Aldo Moro · ITUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large percentage of coronavirus disease 2019 (COVID-19) patients have taste dysfunction. Interleukin 6 (IL-6) levels in mild and moderate COVID-19 patients with the type (quantitative or qualitative) of taste disorders were compared in this observational study. The 208 COVID-19 patients (118 men and 90 women) revealing only taste dysfunctions as prodromic symptoms were classified as mild and moderate patients. Survey results were used to evaluate the taste disorder. The IL-6 levels were measured using a chemiluminescence assay. Statistical analysis was conducted using the Wilcoxon rank, Welch's, and Mann-Whitney tests. The findings revealed that neither the presence of dysgeusia or phantogeusia nor the perception of sour and salty, differed statistically significantly between moderate and mild patients (P > 0.05). But between moderate and mild patients, there were statistically significant differences in how umami, bitter, sweet, and parageusia were perceived (P < 0.05). There was an impairment of multiple tastes up to ageusia in patients with high IL-6 levels. The findings demonstrated that parageusia and dysfunctions in umami, bitter, and sweet taste perception can be indicators of more severe forms of COVID-19.

Indexed as

COVID-19TasteDysgeusiaFemaleHumansInterleukin-6MaleTaste DisordersTaste PerceptionInterleukin-6

Identifiers

PMID35801415
PMCPMC10113942
OpenAlexW4284700468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.