ArticleClinical and experimental dental research2022
Pain intensity and salivary α-amylase activity in patients following mandibular third molar surgery.
Article in Clinical and experimental dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Trial
- The effect of autologous demineralized dentin matrix on postoperative complications and wound healing following lower third molar surgery: A split-mouth randomized clinical trial.Journal of dental sciences · 2025Article
- The Role of Inflammatory Biomarkers (IL-1, IL-6, TNF-α, and Alpha-Amylase) in Saliva on Post-Odontectomy Swelling: A Rapid Review.Journal of inflammation research · 2025Review
- Effects of intracanal cryotherapy on postoperative pain in necrotic teeth with symptomatic apical periodontitis: a randomized controlled clinical trial.Frontiers in dental medicine · 2025Article
- Effectiveness of Lidocaine with Epinephrine Irrigation in Reducing Acute Pain from Surgical Removal of Mesioangular-Impacted Third Molars.Dentistry journal · 2024Article
- Exploring Salivary Alpha-Amylase as a Biomarker in Periodontitis: A Comparative Analysis of Disease Stages and Clinical Correlations.Current issues in molecular biology · 2024Article
- Pain intensity and salivary α-amylase activity in patients following mandibular third molar surgery.Clinical and experimental dental research · 2022Article
- Non-Invasive Objective Markers to Measure Pain: A Direction to Develop a Pain Device - A Narrative Review.Indian journal of palliative careReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to compare the levels of pain and salivary α-amylase (SAA) in patients before and after mandibular third molar surgery. MATERIALS AND
methodsPatients were divided into asymptomatic and symptomatic groups and were then identified by the analgesic drug taken throughout the 2-week study. The visual analog scale (VAS) was employed to evaluate the severity of pain experienced by a given subject before treatment, when the anesthetic wore off, in the morning, and at night for a period of 1 week. Saliva was collected from the mouth floor of the subjects and the levels of SAA activity were measured at indicated times.
resultsThe levels of postoperative pain were higher than those of pretreatment pain (p < 0.05), but were not necessarily different between the two groups. The pain levels were positively correlated with SAA activities in both groups (p < 0.05). There was no difference between the number of analgesics taken by the two groups and the postoperative complications observed during the study. A significant correlation was observed between the VAS pain scale and SAA activities.
conclusionSAA would be a simple effective biomarker for the objective assessment of pain intensity in patients who have undergone mandibular third molar surgery.
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