ArticleFrontiers in public health2022
Global, Regional, and National Burden of Cancer in Children Younger Than 5 Years, 1990-2019: Analysis of the Global Burden of Disease Study 2019.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Trends and projections of high body mass index-associated non-hodgkin lymphoma burden (1990-2040): A global burden of disease 2021 analysis.Annals of hematology · 2026Article
- Real-World Evidence on Hospitalization Costs of Pediatric Neoplasm Patients in China: Patterns, Trends, and Associated Factors From a Retrospective Cohort Study.Cancer medicine · 2026Article
- Global burden and temporal trends of kidney cancer among children from 1990 to 2021: an analysis with projections to 2036.Frontiers in pediatrics · 2026Article
- The national burden of Leukemia in Italy from 1990 to 2023: results from the Global Burden of Disease Study 2023.EClinicalMedicine · 2025Article
- Population based analysis of twenty year incidence trends of pediatric Hodgkin lymphoma in the United States.Scientific reports · 2025Article
- Global, regional, and national burden for childhood and adolescent cancers from 1990 to 2021: from the Global Burden of Disease Study 2021.Pediatric surgery international · 2025Article
- Paediatric Pain Management Experiences of Parents of Children in Botswana Referral Hospitals.Nursing open · 2025Article
- Contemporary epidemiological landscape of pediatric non-Hodgkin lymphoma: a global burden of disease analysis.Frontiers in oncology · 2025Article
- Article
- Disease burden and trends of malignant neoplasm of bone and articular cartilage in childhood in China, 1990-2021 and comparison with United States and India: findings from the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
- Worldwide patterns and trends in childhood and adolescent brain cancers, 1990-2021: insights from the global burden of disease study 2021.Frontiers in public health · 2025Article
- Transcriptome profiling of pediatric extracranial solid tumors and lymphomas enables rapid low-cost diagnostic classification.Scientific reports · 2024Article
- Global, regional, and national burdens of cancer in children aged zero to nine years from 1990 to 2019.Journal of global health · 2024Article
- Cancer mortality in childhood and adolescence: analysis of trends and spatial distribution in the 133 intermediate Brazilian regions grouped by macroregions.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024Article
- Current status and future perspectives of wilms tumor treatment in Iran.Annals of medicine and surgery (2012) · 2023Article
- Review of the Function of the Hypothalamic-Pituitary-Gonadal Axis in Children and Adolescents with Cancer.TouchREVIEWS in endocrinology · 2022Review
- Neuroendocrine Tumors: An Analysis of Prevalence, Incidence, and Survival in a Hospital-Based Study in Ecuador.Healthcare (Basel, Switzerland) · 2022Article
- Global disease burden and trends of leukemia attributable to occupational risk from 1990 to 2019: An observational trend study.Frontiers in public health · 2022Observational
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Abstract
Objectives: To quantify the burden and variation trends of cancers in children under 5 years at the global, regional, and national levels from 1990 to 2019. Methods: Epidemiological data for children under 5 years who were diagnosed with any one childhood cancer were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) from 1990 to 2019. The outcomes were the absolute numbers and rates of incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for different types of cancer. Results: In 2019, 8,774,979.1 incident cases (95% uncertainty interval [UI]: 6,243,599.2 to11,737,568.5) and 8,956,583.8 (6,446,323.9 to 12,364,520.8) prevalent cases of cancer in children under 5 years were identified worldwide; these cancers resulted in 44,451.6 (36,198.7 to 53,905.9) deaths and 3,918,014.8 (3,196,454.9 to 4,751,304.2) DALYs. From 1990 to 2019, although the numbers of incident and prevalent cases only decreased by -4.6% (-7.0 to -2.2) and -8.3% (-12.6 to -3.4), respectively, the numbers of deaths and DALYs clearly declined by -47.8% (-60.7 to -26.4) and -47.7% (-60.7 to -26.2), respectively. In 2019, the middle sociodemographic index (SDI) regions had the highest incidence and prevalence, whereas the low SDI regions had the most mortality and DALYs. Although all of the SDI regions displayed a steady drop in deaths and DALYs between 1990 and 2019, the low-middle and low SDI regions showed increasing trends of incidence and prevalence. Leukemia remained the most common cancer globally in 2019. From 1990 to 2019, the burdens of leukemia, liver cancer, and Hodgkin's lymphoma declined, whereas the incidence and prevalence of other cancers grew, particularly testicular cancer. Conclusions: The global childhood cancer burden in young children has been steadily decreasing over the past three decades. However, the burdens and other characteristics have varied across different regions and types of cancers. This highlights the need to reorient current treatment strategies and establish effective prevention methods to reduce the global burden of childhood cancer.
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