Evidence map›Paper›PMID 35801179›Full record

ArticleFrontiers in neuroscience2022

Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation.

Begüm Aydin, Michael Sierk, Mireia Moreno-Estelles, Link Tejavibulya, Nikathan Kumar, Nuria Flames, Shaun Mahony, Esteban O Mazzoni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Begüm AydinDepartment of Biology, New York University, New York City, NY, United States.
Michael SierkInterdisciplinary Sciences Department, Saint Vincent College, Latrobe, PA, United States.
Mireia Moreno-EstellesDepartment of Biology, New York University, New York City, NY, United States.
Link TejavibulyaDepartment of Biology, New York University, New York City, NY, United States.
Nikathan KumarDepartment of Biology, New York University, New York City, NY, United States.
Nuria FlamesDevelopmental Neurobiology Unit, Instituto de Biomedicina de Valencia IIBV-CSIC, Valencia, Spain.
Shaun MahonyCenter for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States.
Esteban O MazzoniDepartment of Biology, New York University, New York City, NY, United States.
New York University · USInstituto de Biomedicina de Valencia · ESPennsylvania State University · USSaint Vincent College · US

Funding

Understanding the predeterminants of transcription factor regulatory activityR35GM144135 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Shaun Aengus Mahony · 2022 to 2026
$2.4M
A comparative inter-neuronal and inter-species platform to understand neuronal differential sensitivity to neurodegenerationR21AG067174 · NIA · NEW YORK UNIVERSITY · PI MAZZONI, ESTEBAN ORLANDO · 2020 to 2021
$396k
NIA NIH HHS R21 AG067174NIGMS NIH HHS R35 GM144135
6 · The paper itself

Abstract

Neuronal programming by forced expression of transcription factors (TFs) holds promise for clinical applications of regenerative medicine. However, the mechanisms by which TFs coordinate their activities on the genome and control distinct neuronal fates remain obscure. Using direct neuronal programming of embryonic stem cells, we dissected the contribution of a series of TFs to specific neuronal regulatory programs. We deconstructed the Ascl1-Lmx1b-Foxa2-Pet1 TF combination that has been shown to generate serotonergic neurons and found that stepwise addition of TFs to Ascl1 canalizes the neuronal fate into a diffuse monoaminergic fate. The addition of pioneer factor Foxa2 represses Phox2b to induce serotonergic fate, similar to

Indexed as

direct programming methodsFoxa2neuronal differentiationPet1stem cell differentiationtranscription factor

Identifiers

PMID35801179
PMCPMC9254625
OpenAlexW4283212017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.