Evidence map›Paper›PMID 35800886›Full record

ArticleClinical neurophysiology practice2022

The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy.

Serena Pang, Sasha D'Ambrosio, Giulia Battaglia, Diego Jiménez-Jiménez, Marco Perulli, Katri Silvennoinen, Sara Zagaglia, Sanjay M Sisodiya, Simona Balestrini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Serena PangDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Sasha D'AmbrosioDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Giulia BattagliaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Diego Jiménez-JiménezDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Marco PerulliDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Katri SilvennoinenDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Sara ZagagliaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Simona BalestriniDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK.
Epilepsy Society · GBUniversity College London · GBAgostino Gemelli University Polyclinic · ITUniversidad San Francisco de Quito · ECUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To elucidate the effects of single and paired-pulse TMS on seizure activity at electrographic and clinical levels in people with and without epilepsy. Methods: A cohort of 35 people with epilepsy, two people with alternating hemiplegia of childhood (AHC) with no epilepsy, and 16 healthy individuals underwent single or paired-pulse TMS combined with EEG. Clinical records and subject interviews were used to examine seizure frequency four weeks before and after TMS. Results: There were no significant differences in seizure frequency in any subject after TMS exposure. There was no occurrence of seizures in healthy individuals, and no worsening of hemiplegic attacks in people with AHC. Conclusions: No significant changes in seizure activity were found before or after TMS. Significance: This study adds evidence on the safety of TMS in people with and without epilepsy with follow-up of four weeks after TMS.

Indexed as

AHC, Alternating Hemiplegia of ChildhoodAlternating hemiplegia of childhoodASM, Anti-Seizure MedicationCNS, Central Nervous SystemEEG, ElectroencephalographyE:I Ratio, Excitation: Inhibition RatioEMG, ElectromyographyEOG, ElectrooculographyFDI, First Dorsal InterosseusHD-EEG, High-Density EEGICF, Intracortical FacilitationLICI, Long Interval Cortical InhibitionMEP, Motor Evoked PotentialMRI, Magnetic Resonance ImagingMSO, Maximum Stimulator OutputMT, Motor ThresholdPaired pulseppTMS, Paired-pulse TMSPWE, People with EpilepsyQoL, Quality of LifeRMT, Resting Motor ThresholdrTMS, Repetitive TMSSafetySCORE, Standardized Computer-based Organized Reporting of EEGSICI, Short-Interval Intracortical InhibitionSingle pulsespTMS, Single-pulse TMSTEP, TMS-evoked PotentialTMSTMS, Transcranial Magnetic Stimulation

Identifiers

PMID35800886
PMCPMC9254260
OpenAlexW4282827152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.