Evidence map›Paper›PMID 35800848›Full record

ArticleMatter2022

Injectable Liposome-based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs.

Santiago Correa, Abigail K Grosskopf, John H Klich, Hector Lopez Hernandez, Eric A Appel

Open access · greenAbstract read
In one paragraph

Article in Matter, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. A multidomain peptide hydrogel-liposome composite for controlled release of a cyclic dinucleotide in oral cancer.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Condensate nanovaccine adjuvants augment CD8Signal transduction and targeted therapy · 2025
    Article
  14. Enhanced Control of Liposomal Drug Release by Drug-Aptamer Complexes.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  15. Article
  16. Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Santiago CorreaDepartment of Materials Science & Engineering, Stanford University, Stanford, CA 94305, USA.
Abigail K GrosskopfDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
John H KlichDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Hector Lopez HernandezDepartment of Materials Science & Engineering, Stanford University, Stanford, CA 94305, USA.
Eric A AppelDepartment of Materials Science & Engineering, Stanford University, Stanford, CA 94305, USA.
Stanford University · USPalo Alto Institute · US

Funding

Cancer immunotherapy using injectable hydrogels for precise and tunable multidrug deliveryF32CA247352 · NCI · STANFORD UNIVERSITY · PI CORREA, SANTIAGO · 2020 to 2022
$201k
NCI NIH HHS F32 CA247352
6 · The paper itself

Abstract

Directing biological functions is at the heart of next-generation biomedical initiatives in tissue and immuno-engineering. However, the ambitious goal of engineering complex biological networks requires the ability to precisely perturb specific signaling pathways at distinct times and places. Using lipid nanotechnology and the principles of supramolecular self-assembly, we developed an injectable liposomal nanocomposite hydrogel platform to precisely control the release of multiple protein drugs. By integrating modular lipid nanotechnology into a hydrogel, we introduced multiple mechanisms of release based on liposome surface chemistry. To validate the utility of this system for multi-protein delivery, we demonstrated synchronized, sustained, and localized release of IgG antibody and IL-12 cytokine

Indexed as

Controlled deliveryHydrogelsInjectableLiposomesProtein deliveryRheologyViscoelasticity

Identifiers

PMID35800848
PMCPMC9255852
OpenAlexW4284964894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.