ArticleCureus2022
Role of Optical Coherence Tomography to Measure Retinal Nerve Fiber Layer Thickness in Patient With Chronic Obstructive Pulmonary Disease.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Changes in Retinal Nerve Fiber Layer Thickness in Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.The clinical respiratory journal · 2025Pooled it
- Assessment of Retinal Nerve Fiber Layer Changes in Patients With Chronic Kidney Disease: A Cross-Sectional Study.Cureus · 2026Article
- Functional crosstalk between the lung and eye: a new frontier in chronic lung diseases.Archives of toxicology · 2025Review
- Evaluation of Retinal and Posterior Segment Vascular Changes Due to Systemic Hypoxia Using Optical Coherence Tomography Angiography.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to measure retinal nerve fiber layer thickness with spectral domain optical coherence tomography in patients diagnosed with stable chronic obstructive pulmonary disease. And, comparing the RNFL thickness of stable patients with mild to moderate COPD and severe to very severe COPD patients Patients and methods: In this prospective case-control study, a total of 120 patients with chronic obstructive pulmonary disease (COPD) have been selected for measurement of retinal nerve fiber layer on spectral domain-optical coherence tomography (SD-OCT). This study included 120 eyes of participants among which 80 were COPD patients (G1) and 40 were healthy participants (control group: G2). The G1 group is further sub-classified into G1A included 40 eyes of 40 patients with mild to moderate COPD and G1B included 40 eyes of 40 patients with severe to very severe COPD. To determine the hypoxic status of patient arterial blood gas analysis was done. The subfoveal choroidal thickness and retinal nerve fiber thickness were calculated using spectral domain OCT, and these readings of OCT are compared with COPD.
resultsThere was no statistically significant difference between groups according to demographic data. Mean peripapillary retinal nerve fiber layer (RNFL) thickness on SD-OCT was statistically significantly thinner in mild to moderate COPD (106.76±4.39) group and severe to very severe COPD (100.75±4.66) group than in the control group (108.51±4.39); this thinning was more pronounced with increase in the severity of COPD. On comparing macular thickness between three groups, it was found that there were no statistically significant differences in macular thickness (MT) (p=0.684)
conclusionChanges in the SD-OCT and retinal nerve fiber layer (RNFL) thickness could be used as indicators for the severity of COPD. And, it can also aid in the early intervention to hypoxic changes in the retina there by decreasing the chances of visual field defect.
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Registered trials
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