Evidence map›Paper›PMID 35800670›Full record

ArticleTranslational and clinical pharmacology2022

Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination.

Hyun Chul Kim, Deok Yong Yoon, SeungHwan Lee, In-Jin Jang, Jang Hee Hong, JaeWoo Kim

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Translational and clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01606059 (A Randomized, Open Label, 2-treatment, 2-sequence, Cross-over Study to Compare the Safety and Pharmacokinetics of DW-0919 and DW-0920 After Single Oral Administration in Healthy Male Volunteers), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01606059 phase1completednot on this map

A Randomized, Open Label, 2-treatment, 2-sequence, Cross-over Study to Compare the Safety and Pharmacokinetics of DW-0919 and DW-0920 After Single Oral Administration in Healthy Male Volunteers

TypeinterventionalSponsorDaewon Pharmaceutical Co., Ltd.Ran2012 to 2012Enrolled30ConditionsHealthyArmsDW-0920, DW-0919
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hyun Chul KimDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-8819-4780
Deok Yong YoonDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-5281-8811
SeungHwan LeeDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-1713-9194
In-Jin JangDepartment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea.ORCID https://orcid.org/0000-0002-8384-3139
Jang Hee HongClinial Trials Center, Chungnam National University Hospital, Daejeon 35015, Korea.ORCID https://orcid.org/0000-0002-0623-5455
JaeWoo KimH Plus Yangji Hospital, Seoul 08779, Korea.ORCID https://orcid.org/0000-0002-3511-9330
Seoul National University Hospital · KRChungnam National University · KREulji Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An extended-release (ER) fixed-dose combination (FDC) of tramadol 37.5 mg/acetaminophen 325 mg was developed due to the demand for varying dosages. This study aimed to evaluate the pharmacokinetics (PKs) for two tablets of the new developed tramadol 37.5 mg/acetaminophen 325 mg ER FDC (DW-0920, Wontran Semi ER Trial Registration: ClinicalTrials.gov Identifier: NCT01606059.

Indexed as

AcetaminophenDrug CombinationExtended Release FormulationPharmacokineticsTramadol

Identifiers

PMID35800670
PMCPMC9253448
OpenAlexW4284976311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.