Evidence map›Paper›PMID 35800623›Full record

ArticleSpine surgery and related research2022

Intradiscal Injection with Condoliase (Chondroitin Sulfate ABC Endolyase) for Painful Radiculopathy Caused by Lumbar Disc Herniation.

Takashi Hirai, Takuya Takahashi, Tomoyuki Tanaka, Takayuki Motoyoshi, Yu Matsukura, Masato Yuasa, Hiroyuki Inose, Toshitaka Yoshii, Atsushi Okawa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spine surgery and related research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Takashi HiraiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Takuya TakahashiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Tomoyuki TanakaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Takayuki MotoyoshiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Yu MatsukuraDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Masato YuasaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroyuki InoseDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Toshitaka YoshiiDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Atsushi OkawaDepartment of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chemonucleolysis with condoliase (chondroitin sulfate ABC endolyase) has been used to treat patients with lumbar disc herniation (LDH) in Japan since 2018. In this study, we retrospectively investigated clinical outcomes in patients who received an intradiscal condoliase injection for LDH and sought to identify significant predictors of good outcome. Methods: Indications for treatment were as follows: (1) unilateral leg pain with or without back pain, (2) nerve root compression caused by LDH confirmed on magnetic resonance imaging (MRI), and (3) leg pain resistant to at least 1 month of conservative treatment, including medication, nerve root block, or physical therapy. Patients with motor weakness or a history of severe allergy were excluded, as were those with the foraminal or sequestrated type of LDH. The injection was defined as effective if the numeric rating scale score for leg pain improved by ≥50% at 6 months post-treatment. Results: A total of 52 patients (mean age, 45.0 years) were enrolled and classified according to whether the injection was effective (E group, n=40, 76.9%) or less effective (L group, n=9, 17.3%). Three patients (5.8%) underwent herniotomy for residual pain within 6 months of the injection. There were no severe adverse events. Reduction of herniation was seen on MRI more often in the E group than in the L group. The effectiveness in patients with transligamentous LDH was similar to that in patients with subligamentous LDH. High-intensity signal change in the area of LDH on pretreatment T2-weighted MRI was a significant predictor of successful leg pain relief. Conclusions: An intradiscal condoliase injection was a safe and effective treatment for painful radiculopathy caused by LDH. Leg pain was more likely to improve in patients with high-intensity signal change in the area of LDH before treatment.

Indexed as

chemonucleolysiscondoliasehigh-intensity signal changeIntradical injectionleg painlow back painlumbar intervertebral disc herniationradiculopathy

Identifiers

PMID35800623
PMCPMC9200423
OpenAlexW3206393557

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.