Evidence map›Paper›PMID 35800619›Full record

ArticleBiochemistry and biophysics reports2022

CA10 is associated with HBV-related hepatocarcinogenesis.

Kuei-Min Chung, Ya-Ting Chen, Chih-Chen Hong, Il-Chi Chang, Si-Ying Lin, Li-Yu Liang, Yi-Rong Chen, Chau-Ting Yeh, Shiu-Feng Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Carbonic Anhydrase Inhibitors in Oncology.Sub-cellular biochemistry · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kuei-Min ChungInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Ya-Ting ChenInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Chih-Chen HongInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Il-Chi ChangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Si-Ying LinInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Li-Yu LiangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Yi-Rong ChenInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Chau-Ting YehLiver Research Unit, Linko Chang Gung Memorial Hospital, Chang-Gung University, Taoyuan, Taiwan.
Shiu-Feng HuangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
National Health Research Institutes · TWChang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the main threat for the patients infected with hepatitis B virus (HBV), but the oncogenic mechanism of HBV-related HCC is still controversial. Previously, we have found that several HBV surface gene (HBS) non-sense mutations are oncogenic. Among these mutations, sW182* was found to have the most potent oncogenicity. In this study, we found that Carbonic Anhydrase X (CA10) level was specifically increased in sW182* mutant-expressing cells. CA10 overexpression was also associated with HBS nonsense mutation in HBV-related HCC tumor tissues. Transformation and tumorigenesis assays revealed that CA10 had significant oncogenic activity. In addition, CA10 overexpression resulted in dysregulation of apoptosis-related proteins, including Mcl-1, Bcl-2, Bcl-xL and Bad. While searching for the regulatory mechanism of CA10, miR-27b was found to downregulate CA10 expression by regulating its mRNA degradation and its expression was decreased in sW182* mutant cells. Moreover, CA10 overexpression was associated with down-regulation of miR-27b in human HBV-related HCC tumor tissues with sW182* mutation. Therefore, induction of the expression of CA10 through repression of miR-27b by sW182* might be one mechanism involved in HBS mutation-related hepatocarcinogenesis.

Indexed as

Bad, BCL2-antagonist of cell death geneBcl-2, B-cell lymphoma 2 geneBcl-XL, B-cell lymphoma-extra large geneCA10CA10, Carbonic Anhydrase XHBS, HBV surface geneHBVHBV, hepatitis B virusHCCHCC, hepatocellular carcinomaMcl-1, myeloid cell leukemia 1 genemiR-27bsW182*, HBS gene with W182 nonsense mutationW182 nonsense mutation

Identifiers

PMID35800619
PMCPMC9254355
OpenAlexW4283757854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.