Evidence map›Paper›PMID 35800578›Full record

ArticleJournal of family medicine and primary care2022

Derivation of a Modified Friedewald's equation for LDL cholesterol estimation in Sub-Himalayan population: A comparative study.

Parmila Dudi, Vishwajeet, Shashi Ranjan Mani Yadav, Poonam Sharma, Prashant Kumar, Anissa A Mirza, Manisha Naithani, Satyavati Rana, Bela Goyal

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Article in Journal of family medicine and primary care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Parmila DudiDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
VishwajeetDepartment of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Shashi Ranjan Mani YadavDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Poonam SharmaDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Prashant KumarDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Anissa A MirzaDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Manisha NaithaniDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Satyavati RanaDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Bela GoyalDepartment of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

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6 · The paper itself

Abstract

Background: Despite the availability of alternative homogenous assays for LDL-C measurement, most of the laboratories still use Friedewald Equation (FE). However, various novel equations have shown better performance than FE specific to a particular population. Besides, no equation has been devised for use in Sub-Himalayan population. Methods: A cross-sectional laboratory data-based study was conducted by recruiting lipid profiles of 1851 samples to validate 10 different equations for calculating LDL and to devise a novel Modified Friedewald Equation (MFE) specific for Sub-Himalayan population. Results: The novel MFE is presented as: LDL-C = -2.421 + (0.752 × TC) - (0.047 × TG) - (0.350 × HDL). A significant difference was observed between direct LDL-C (118.84 ± 40.39 mg/dL) and all other equations except MFE (118.84 ± 37.96 mg/dl, Conclusion: MFE derived in this study showed a better diagnostic performance as compared to other 10 equations taking Direct LDL-C as gold standard for Sub-Himalayan Population and may be used as a substitute for FE in the study population.

Indexed as

Equation derivationlow density lipoprotein (LDL-C)regression analysissub-Himalayan population

Identifiers

PMID35800578
PMCPMC9254838

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