ArticleTranslational pediatrics2022
Risk factors for neonatal hyperbilirubinemia: a systematic review and meta-analysis.
Article in Translational pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Neonatal Intensive Care Admissions and Outcomes in Malta from 2019 to 2022-A Retrospective Observational Study.Children (Basel, Switzerland) · 2026Article
- Efficacy of zinc sulfate in neonatal hyperbilirubinemia: a meta-analysis of randomized controlled trials.Frontiers in pediatrics · 2026Review
- Evaluation of Thermal, Hematohistological, and Dermatological Biocompatibility of LED Devices for Neonatal Phototherapy.Biomedicines · 2025Article
- The critical role of diagnostic accuracy in differentiating uterine dehiscence and placenta accreta spectrum to enhance neonatal outcomes in complex cesarean sections.BMC pregnancy and childbirth · 2025Article
- Factors associated with neonatal jaundice among neonates admitted to three hospitals in Burao, Somaliland: a facility-based unmatched case-control study.BMC pediatrics · 2025Article
- Article
- Exploring the Association Between Glucose-6-Phosphate Dehydrogenase Deficiency and Autism Spectrum Disorder: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Neonatal Jaundice Requiring Phototherapy Risk Factors in a Newborn Nursery: Machine Learning Approach.Children (Basel, Switzerland) · 2025Article
- Study of the Variability of Transcutaneous Bilirubin Determinations Between Different Ethnic Groups.Children (Basel, Switzerland) · 2025Article
- Hematological parameter changes and associated factors in neonates with hyperbilirubinemia treated with phototherapy.BMC pediatrics · 2025Article
- Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia.Heliyon · 2025Article
- The Effect of Maternal Diet on Neonatal Jaundice: A Case-Control Study.Sultan Qaboos University medical journal · 2025Article
- Construction and Evaluation of a Prediction Model for Neonatal Hyperbilirubinemia.International journal of general medicine · 2025Article
- Study to correlate the parental judgement of neonatal jaundice using clinical and biochemical profile.Bioinformation · 2025Article
- Causal association between pregnancy disorders and neonatal jaundice: a two-sample Mendelian randomization study.Translational pediatrics · 2024Article
- Development and validation of a prediction model for rebound hyperbilirubinemia: a Chinese neonatal cohort study.Translational pediatrics · 2024Article
- Hematological abnormality and associated factors in newborns with hyperbilirubinemia before and after phototherapy at University of Gondar Comprehensive Specialized Hospital.Scientific reports · 2024Article
- The application value of mean red blood cell volume and red blood cell volume distribution width combined with total serum bilirubin in the early screening of neonatal hemolytic disease.BMC pediatrics · 2023Article
- Determinants of neonatal jaundice among neonates admitted to neonatal intensive care unit in public hospitals of Sidama Region, Sidama, Ethiopia, 2022: an unmatched case-control study.The Pan African medical journal · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hyperbilirubinemia is the most common cause of neonatal hospitalization and, although it generally has a good prognosis, a significant percentage of neonatal patients maintain a high bilirubin level, which can lead to severe complications, including lifelong disability such as growth retardation, encephalopathy, autism and hearing impairment. The study of risk factors for neonatal hyperbilirubinemia has been controversial. Therefore, we evaluated the risk factors of neonatal hyperbilirubinemia using a meta-analysis. Methods: Relevant English and Chinese studies that discussed risk factors for neonatal hyperbilirubinemia were retrieved from the PubMed, EMBASE, Medline, Central, China National Knowledge Infrastructure (CNKI), Wanfang and China Science Digital Library (CSDL). The literature took newborns as the research object, set up a control group, and observed the relationship between exposure factors and neonatal hyperbilirubinemia. The combined effect size was expressed by odds ratio (OR) and 95% confidence interval (CI). The Chi-square test was used to test heterogeneity of the studies, and if it existed, subgroup analyses were used to explore the source of heterogeneity, and the random-effects model was selected for the combined analysis. The fixed-effects model was chosen for the combined analysis if there was no heterogeneity. Publication bias was assessed using Egger's test and funnel plot. Results: Risk factors for neonatal hyperbilirubinemia were exclusive breastfeeding (BF: OR =1.74, 95% CI: 1.42, 2.12, Z=5.43, P<0.00001); glucose-6-phosphate dehydrogenase deficiency (G6PD: OR =1.62, 95% CI: 1.44, 1.81, Z=8.39, P<0.00001); maternal-fetal ABO blood group incompatibility (OR =1.64, 95% CI: 1.42, 1.89, Z=6.75, P<0.00001); and preterm birth (PTB: OR =1.31, 95% CI: 1.17, 1.47, Z=4.60, P<0.00001); there was no heterogeneity or publication bias among the studies (BF: χ Conclusions: Exclusive breastfeeding, G6PD deficiency, ABO incompatibility and premature birth were confirmed as risk factors for neonatal hyperbilirubinemia. Pregnant women with risk factors should be monitored more closely and clinical intervention should be given in a timely manner.
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