Evidence map›Paper›PMID 35800258›Full record

ArticlePathogens & immunity2022

Why Does Doxycycline Pose a Relatively Low Risk for Promotion of

Dongyan Xu, Thriveen S C Mana, Jennifer L Cadnum, Abhishek Deshpande, Faezeh Afsari, Naseer Sangwan, Curtis J Donskey

Open access · diamondAbstract read
In one paragraph

Article in Pathogens & immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Clinical microbiology reviews · 2024
    Review
  4. Article
  5. Article
  6. Antibiotic-Specific Risk for Community-AcquiredAntimicrobial agents and chemotherapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Dongyan XuCase Western Reserve University School of Medicine, Cleveland, Ohio.
Thriveen S C ManaResearch Service, Cleveland VA Medical Center, Cleveland, Ohio.
Jennifer L CadnumResearch Service, Cleveland VA Medical Center, Cleveland, Ohio.
Abhishek DeshpandeCenter for Value-Based Care Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
Faezeh AfsariLerner Research Institute/Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
Naseer SangwanLerner Research Institute/Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
Curtis J DonskeyCase Western Reserve University School of Medicine, Cleveland, Ohio.
Cleveland Clinic Lerner College of Medicine · USLouis Stokes Cleveland VA Medical Center · USGeriatric Research Education and Clinical Center · USUniversity School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clinical studies suggest that doxycycline poses a low risk for promotion of Methods: Mice treated with oral doxycycline, oral azithromycin, subcutaneous ceftriaxone, doxycycline plus ceftriaxone, or azithromycin plus ceftriaxone were challenged with 10 Results: Doxycycline and azithromycin treatment did not promote colonization by either Conclusions: These findings suggest that doxycycline may have a low propensity to promote

Indexed as

azithromycinClostridioides difficiledoxycyclinemicrobiome

Identifiers

PMID35800258
PMCPMC9254868
OpenAlexW4283319490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.