Evidence map›Paper›PMID 35800179›Full record

ArticleWorld journal of gastroenterology2022

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study.

Sabrina Berens, Yuanjun Dong, Nikola Fritz, Jutta Walstab, Mauro D'Amato, Tenghao Zheng, Verena Wahl, Felix Boekstegers, Justo Lorenzo Bermejo, Cristina Martinez and 23 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 1 institution in 1 country.

Sabrina BerensDepartment of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg 69120, Germany.
Yuanjun DongDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Nikola FritzDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Jutta WalstabDepartment of Human Molecular Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Mauro D'AmatoGastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio 48160, Spain.
Tenghao ZhengUnit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm 17177, Sweden.
Verena WahlDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Felix BoekstegersInstitute of Medical Biometry and Informatics, Heidelberg University, Heidelberg 69120, Germany.
Justo Lorenzo BermejoInstitute of Medical Biometry and Informatics, Heidelberg University, Heidelberg 69120, Germany.
Cristina MartinezDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Stefanie SchmitteckertDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Egbert CleversDepartment of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven 3000, Belgium.
Felicitas EngelDepartment of General Internal Medicine and Psychosomatics, Internal Medicine II, University Hospital Heidelberg, Heidelberg 69120, Germany.
Annika GaussDepartment of Gastroenterology, Infectious Diseases and Intoxications, University of Heidelberg, Heidelberg 69120, Germany.
Wolfgang HerzogDepartment of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg 69120, Germany.
Robin SpillerNottingham Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2QL, United Kingdom.
Miriam Goebel-StengelHelios Klinikum Rottweil, Rottweil 78628, Germany.
Hubert MönnikesDepartment of Medicine, Institute of Neurogastroenterology (H.M.), Martin-Luther-Hospital, Belin 14193, Germany.
Viola AndresenIsraelitisches Krankenhaus in Hamburg, Hamburg 22297, Germany.
Frieling ThomasInternal Medicine II, Helios Klinikum Krefeld, Krefeld 47805, Germany.
Jutta KellerIsraelitisches Krankenhaus Hamburg, Hamburg 22297, Ghana.
Christian PehlKrankenhaus Vilsbiburg, Vilsbiburg 84137, Germany.
Christoph Stein-ThöringerDivision of Microbiome and Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Gerard ClarkeDepartment of Psychiatry and Neurobehavioral Science, University College Cork, Cork T23, Ireland.
Timothy G DinanDepartment of Psychiatry and Neurobehavioral Science, University College Cork, Cork T23, Ireland.
Eamonn M QuigleyMedicine in Digestive Disorders, Department of Medicine, Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist, Houston, TX 77030, United States.
Gregory SayukDivision of Gastroenterology, Washington University School of Medicine, Department of Psychiatry, School of Medicine, John Cochran Veteran Affairs Medical Center, St. Louis, MO 63110, United States.
Magnus SimrénDepartment of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg SE-41685, Sweden.
Jonas TesarzDepartment of General Internal Medicine and Psychosomatics, Internal Medicine II, University Hospital Heidelberg, Heidelberg 69120, Germany.
Gudrun RappoldDepartment of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany.
Lukas van OudenhoveCognitive and Affective Neuroscience Lab, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03748, United States.
Rainer SchaefertDepartment of General Internal Medicine and Psychosomatics, Internal Medicine II, University Hospital Heidelberg, Heidelberg 69120, Germany.
Beate NieslerInterdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Heidelberg 69120, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSingle-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit (

aimTo assess the association of

methodsIn this retrospective study, 623 participants with IBS were recruited from five specialty centers in Germany, Sweden, the United States, the United Kingdom, and Ireland. Depressive, anxiety, and somatization symptoms and sociodemographic characteristics were collected. Four functional SNPs -

resultsDepressive and anxiety symptoms significantly worsened with increasing numbers of minor

conclusionWe have provided the first evidence that

Indexed as

Irritable Bowel SyndromeAllelesHumansPolymorphism, Single NucleotideReceptors, Serotonin, 5-HT3Retrospective StudiesSerotoninHTR3A protein, humanReceptors, Serotonin, 5-HT3Serotonin5-HT3 receptor subunit gene polymorphismsAnxietyDepressionIrritable bowel syndromeSingle-nucleotide polymorphism scoreSomatization

Identifiers

PMID35800179
PMCPMC9185212
OpenAlexW4283382725

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.