Evidence map›Paper›PMID 35800158›Full record

ArticleOncoimmunology2022

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer.

Raquel S Laureano, Jenny Sprooten, Isaure Vanmeerbeerk, Daniel M Borras, Jannes Govaerts, Stefan Naulaerts, Zwi N Berneman, Benoit Beuselinck, Kalijn F Bol, Jannie Borst and 15 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Guideline
  2. Personalized neoantigen mRNA vaccines for pancreatic cancer: the role of lipid nanoparticle delivery systems.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Pharmaceutics · 2025
    Article
  18. Review
  19. Review
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 5 countries.

Raquel S LaureanoLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Jenny SprootenLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Isaure VanmeerbeerkLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Daniel M BorrasLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Jannes GovaertsLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Stefan NaulaertsLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1880-6374
Zwi N BernemanDepartment of Haematology, Antwerp University Hospital, Edegem, Belgium.
Benoit BeuselinckDepartment of General Medical Oncology, UZ Leuven, Leuven, Belgium.
Kalijn F BolDepartment of Tumour Immunology, Radboud Institute for Molecular Life Sciences; Radboud University Medical Center, Nijmegen, The Netherlands.
Jannie BorstDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
An CoosemansDepartment of Oncology, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, Ku Leuven, Leuven Cancer Institute, Leuven, Belgium.
Angeliki DatsiInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine University, Düsseldorf, Germany.
Jitka FučíkováSotio Biotech, Prague, Czech Republic.
Lisa KingetDepartment of General Medical Oncology, UZ Leuven, Leuven, Belgium.
Bart NeynsDepartment of Medical Oncology, UZ Brussel, Brussels, Belgium.
Gerty SchreibeltDepartment of Tumour Immunology, Radboud Institute for Molecular Life Sciences; Radboud University Medical Center, Nijmegen, The Netherlands.
Evelien SmitsCenter for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Edegem, Belgium.
Rüdiger V SorgInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine University, Düsseldorf, Germany.
Radek SpisekSotio Biotech, Prague, Czech Republic.
Kris ThielemansLaboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Brussels, Belgium.
Sandra TuyaertsDepartment of Medical Oncology, UZ Brussel, Brussels, Belgium.
Steven De VleeschouwerResearch Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium.
I Jolanda M de VriesDepartment of Tumour Immunology, Radboud Institute for Molecular Life Sciences; Radboud University Medical Center, Nijmegen, The Netherlands.
Yanling XiaoDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.
Abhishek D GargLaboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-9976-9922
KU Leuven · BERadboud University Nijmegen · NLUniversitair Ziekenhuis Leuven · BECharles University · CZHeinrich Heine University Düsseldorf · DELeiden University Medical Center · NLUniversity of Antwerp · BEVrije Universiteit Brussel · BEUniversitair Ziekenhuis Brussel · BEVIB-KU Leuven Center for Cancer Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable development over recent decades. However, this field is currently in a state of flux toward niche-applications, owing to recent paradigm-shifts in immuno-oncology mobilized by T cell-targeting immunotherapies. DC vaccines are typically generated using autologous (patient-derived) DCs exposed to tumor-associated or -specific antigens (TAAs or TSAs), in the presence of immunostimulatory molecules to induce DC maturation, followed by reinfusion into patients. Accordingly, DC vaccines can induce TAA/TSA-specific CD8

Indexed as

Cancer VaccinesNeoplasmsAntigens, NeoplasmDendritic CellsHumansImmunotherapyAntigens, NeoplasmCancer Vaccinesantigen cross-presentationclinical trialDAMPsDendritic cellsimmune checkpoint blockersTAAsT cell primingtumor-infiltrating lymphocytes

Identifiers

PMID35800158
PMCPMC9255073
OpenAlexW4283796991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.