ArticleFrontiers in oncology2022
Platelet-to-Lymphocyte Ratio and CA125 Level as a Combined Biomarker for Diagnosing Endometriosis and Predicting Pelvic Adhesion Severity.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Association of platelets and platelet-related parameters (PLT/MPV/PLR) in endometriosis: a meta-analysis.BMC women's health · 2026Pooled it
- Acupuncture monotherapy for endometriosis-related pain: A systematic review and meta-analysis.Medicine · 2025Pooled it
- The Diagnostic Role of the Platelet-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Comparing and combining O-RADS ultrasound, serum CA125, and HE4 for the preoperative diagnosis of ovarian tumors.BMC medical imaging · 2026Article
- CA125 Outperforms HE4 and CA19-9 as a Serum Biomarker for Preoperative Diagnosis of Ovarian Endometriomas: A Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Preoperative differentiation of borderline and malignant ovarian tumors using interpretable machine learning.Journal of ovarian research · 2026Article
- The Fibrinogen-to-Albumin Ratio in Endometriosis: A Step Toward Personalized Non-Invasive Diagnostics.Journal of personalized medicine · 2026Article
- Risk Factors of Adolescent Endometriosis Onset and Recurrence: A Retrospective Study.International journal of women's health · 2026Article
- Can hematological and biochemical parameters clinically predict the diagnosis of deep infiltrating endometriosis?BMC women's health · 2025Article
- Uterine artery S/D ratio and serum CA125 as predictors of early pregnancy loss in women with ovarian endometriomas: a retrospective case-control study.BMC pregnancy and childbirth · 2025Article
- Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients.The journal of obstetrics and gynaecology research · 2025Article
- Article
- Platelet Count and Platelet Hematocrit Correlate to the Occurrence and Postoperative Recurrence in Intrauterine Adhesion Patients.International journal of women's health · 2025Article
- The diagnostic value of serum inflammation, coagulation and tumor indexes in differentiating stage III and IV ovarian endometriotic cysts.Frontiers in medicine · 2025Article
- The Role of Inflammatory Markers NLR and PLR in Predicting Pelvic Pain in Endometriosis.Journal of clinical medicine · 2024Article
- Article
- Endometrial expression of ERRβ and ERRγ: prognostic significance and clinical correlations in severe endometriosis.Frontiers in endocrinology · 2024Article
- Postoperative Peritoneal Granulomatous Inflammation After the Application of Potato Starch-Based Anti-Adhesive Agent in Laparoscopic Endometriosis Surgery.Facts, views & vision in ObGyn · 2023Article
- Inflammatory Markers in Women with Infertility: A Cross-Sectional Study.International journal of general medicine · 2023Article
- Overexpression of lncRNA-MEG3 inhibits endometrial cell proliferation and invasion via miR-21-5p/DNMT3B/Twist.Clinics (Sao Paulo, Brazil) · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion is a significant biological characteristic of endometriosis, and accurate evaluation of the pelvic adhesion is necessary for surgical treatment. Serum CA125 is yet the most common used biomarker in the diagnosis and follow-up of patients with endometriosis despite of its high false-positive rate and low specificity. Herein, we aimed to examine the diagnostic value of the combination of the platelet-to-lymphocyte ratio (PLR) and CA125 for patients with different stages of endometriosis and their correlations with pelvic adhesion. We retrospectively analyzed the clinical data and blood count parameters of patients with both endometriosis and other benign ovarian tumors. The mean level of CA125, the PLR and the combined marker (the CA125 level multiplied by the PLR) in the EMs group were significantly higher than those in the Cyst group (P < 0.05). ROC curve analysis was used to compare the diagnostic values of serum PLR, CA125, and the combined marker in ovarian endometriosis. The cut-off value of the PLR was 176.835, with 28.3% sensitivity and 96.9% specificity. The cut-off value of CA125 was 31.67 U/mL, with 84.1% sensitivity and 87.4% specificity. The cut-off value of the combined marker was 3894.97, with 83.4% sensitivity and 95.8% specificity. It was found that the severity of adhesion in endometriosis was positively correlated with the PLR (r = 0.286, P < 0.01), CA125 (r = 0.276, P < 0.01), and combined marker (r = 0.369, P < 0.01). The combined marker showed the highest AUC value (0.751, 95% CI: 0.666-0.837), with a sensitivity of 56.0% and a specificity of 89.6%, and the cut-off value was 9056.94. Besides, the levels of CA125, PLR, and their combination were significantly elevated in patients with endometriosis. The combined marker was not only positively correlated with pelvic adhesion but also showed a greater diagnostic value and specificity than CA125 alone. These findings indicate that the combined marker may be a potential inflammatory biomarker playing an important role in the diagnosis and assessment of adhesion in endometriosis.
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