Evidence map›Paper›PMID 35799538›Full record

ArticleNeural regeneration research2023

Early brainstem hemorrhage progression: multi-sequence magnetic resonance imaging and histopathology.

Xi Guo, Jia-Ke Xu, Xin Qi, Yang Wei, Cheng-Wei Wang, Hao Li, Lu Ma, Chao You, Meng Tian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xi GuoDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Jia-Ke XuDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Xin QiDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Yang WeiDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Cheng-Wei WangDepartment of Integrated Traditional and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province; Department of Rehabilitation, People's Hospital of Karamay, Karamay, Xinjiang Uygur Autonomous Region, China.
Hao LiDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Lu MaDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Chao YouDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics; West China Brain Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Meng TianDepartment of Neurosurgery and Neurosurgery Research Laboratory, National Clinical Research Center for Geriatrics; West China Brain Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Sichuan University · CNKaramay Central Hospital · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to clinical statistics, the mortality of patients with early brainstem hemorrhage is high. In this study, we established rat models of brainstem hemorrhage by injecting type VII collagenase into the right basotegmental pontine and investigated the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological methods. We found that brainstem hematoma gradually formed in the injured rats over the first 3 days and then reduced after 7 days. The edema that occurred was mainly of the vasogenic type. No complete myelin sheath structure was found around the focus of the brainstem hemorrhage. The integrity and continuity of nerve fibers gradually deteriorated over the first 7 days. Neuronal degeneration was mild in the first 3 days and then obviously aggravated on the 7

Indexed as

brainstem hemorrhagediffuse tensor imagingdiffusion-weighted imagingFluoro-Jade C staininghematoxylin-eosin staininginterleukin-1βluxol fast bluerat modelT2-weighted imagingtumor necrosis factor-α

Identifiers

PMID35799538
PMCPMC9241409
OpenAlexW4229009657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.