ArticleThe Journal of frailty & aging2022
Differences in Muscle Quantity and Quality by HIV Serostatus and Sex.
Article in The Journal of frailty & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sarcopenic Obesity in People With HIV: Diagnostic Criteria and Classification-A Scoping Review With a Meta-Analysis of Prevalence.Journal of obesity · 2026Pooled it
- No evidence of pitavastatin effect on muscle area or density among people with HIV.AIDS (London, England) · 2025 · on this mapTrial
- Effects of Semaglutide on Muscle Structure and Function in the SLIM LIVER Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Trial
- Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026Review
- Density of ectopic fat depots predict distinct biomarkers of glycemic and insulinemic status in persons with HIV.Nutrition & diabetes · 2025Article
- Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Review
- Current Challenges, Solutions, and Novel Directions in Research and Clinical Care: Proceedings From the 14th Annual International Workshop on HIV and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Sex Differences in Metabolic Disorders of Aging and Obesity in People with HIV.Current HIV/AIDS reports · 2024Review
- Muscle Quality and Physical Function in Men With and Without HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Cardiometabolic Characteristics of Obesity Phenotypes in Persons With HIV.Open forum infectious diseases · 2024Article
- The use of non-invasive imaging modalities for the assessment of skeletal muscle quantity and quality in people with HIV: A narrative review.HIV medicine · 2023Review
- Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with HIV.Alcoholism, clinical and experimental research · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectivePeople with HIV (PWH) experience greater declines in both muscle function and muscle mass with aging. Whether changes in muscle quality and quantity with aging differ between men and women with HIV and the implications on muscle function are not established.
designIn coordinated substudies of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study, participants completed physical function and falls assessments; total trunk/thigh density, inversely related to fatty infiltration, and area were quantified from computed tomography (CT) scans.
methodsGeneralized linear models were used to explore variables affecting density/area, and associations between area/density and physical function and falls.
resultsCT scans were available on 387 men (198 PWH) and 184 women (118 PWH). HIV serostatus was associated with greater lateralis, paraspinal, and hamstring area, but lower psoas area and density. Older age and female sex were associated with smaller trunk muscle area and lower density. Both lower muscle area and muscle density were associated with several measures of impaired physical function. The odds of falling were lower with greater hamstring density, but not associated with other measurers of muscle area or density.
conclusionsIn summary, older adults with HIV appear to have smaller and less dense (fattier) psoas, a key component in truncal stability and hip flexion that could have implications on physical function. The longitudinal associations of muscle area and density with physical function require careful investigation, with a particular focus on characteristics and interventions that can preserve muscle area, density, and function over time.
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