Evidence map›Paper›PMID 35799288›Full record

ArticleJournal of intensive care2022

ARDS Clinical Practice Guideline 2021.

Sadatomo Tasaka, Shinichiro Ohshimo, Muneyuki Takeuchi, Hideto Yasuda, Kazuya Ichikado, Kenji Tsushima, Moritoki Egi, Satoru Hashimoto, Nobuaki Shime, Osamu Saito and 38 more

Registry-linked trialOpen access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05689216 (Efficacy of Timed Awake Prone and Repositioning in Patients With Covid-19-induced Hypoxic Respiratory Failure), which is not on this map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05689216 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Efficacy of Timed Awake Prone and Repositioning in Patients With Covid-19-induced Hypoxic Respiratory Failure: a Multi-center, Randomized Controlled Trial.

TypeinterventionalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2023 to 2024Enrolled286ConditionsCorona Virus Infection, Hypoxic Respiratory FailureArmsAwake timed prone and repositioning
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Guideline
  3. Predictive Value of the PaOInternal medicine (Tokyo, Japan) · 2025
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. The research progress of ferroptosis in acute lung injury.Biochemistry and biophysics reports · 2026
    Review
  10. Article
  11. Saudi Guideline for Mechanical Ventilation in Adults.Saudi journal of medicine & medical sciences · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 2 countries.

Sadatomo TasakaDepartment of Respiratory Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, Aomori, 036-8562, Japan. tasaka@hirosaki-u.ac.jp.
Shinichiro OhshimoDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Muneyuki TakeuchiDepartment of Intensive Care Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.
Hideto YasudaDepartment of Emergency and Critical Care Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Kazuya IchikadoDivision of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Kenji TsushimaInternational University of Health and Welfare, Tokyo, Japan.
Moritoki EgiDepartment of Anesthesiology, Kobe University Hospital, Hyogo, Japan.
Satoru HashimotoDepartment of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Nobuaki ShimeDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Osamu SaitoDepartment of Pediatric Emergency and Critical Care Medicine, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Shotaro MatsumotoDivision of Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan.
Eishu NangoDepartment of Family Medicine, Seibo International Catholic Hospital, Tokyo, Japan.
Yohei OkadaDepartment of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kenichiro HayashiDepartment of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan.
Masaaki SakurayaDepartment of Emergency and Intensive Care Medicine, JA Hiroshima General Hospital, Hiroshima, Japan.
Mikio NakajimaEmergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Satoshi OkamoriDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shinya MiuraPaediatric Intensive Care Unit, The Royal Children's Hospital, Melbourne, Australia.
Tatsuma FukudaDepartment of Emergency and Critical Care Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Tadashi IshiharaDepartment of Emergency and Critical Care Medicine, Urayasu Hospital, Juntendo University, Chiba, Japan.
Tetsuro KamoDepartment of Critical Care Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Tomoaki YatabeDepartment of Anesthesiology, Nishichita General Hospital, Tokai, Japan.
Yasuhiro NorisueTokyo Bay Urayasu Ichikawa Medical Center, Chiba, Japan.
Yoshitaka AokiDepartment of Anesthesiology and Intensive Care Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
Yusuke IizukaDepartment of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Yutaka KondoDepartment of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, Chiba, Japan.
Chihiro NaritaDepartment of Emergency Medicine, Shizuoka General Hospital, Shizuoka, Japan.
Daisuke KawakamiDepartment of Anesthesia and Critical Care, Kobe City Medical Center General Hospital, Hyogo, Japan.
Hiromu OkanoDepartment of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Kanagawa, Japan.
Jun TakeshitaDepartment of Anesthesiology, Osaka Women's and Children's Hospital, Osaka, Japan.
Keisuke AnanDivision of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kyoto, Japan.
Satoru Robert OkazakiDepartment of Intensive Care Medicine, Kameda Medical Center, Chiba, Japan.
Shunsuke TaitoDivision of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan.
Takuya HayashiPediatric Emergency and Critical Care Center, Saitama Children's Medical Center, Saitama, Japan.
Takuya MayumiDepartment of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Takero TerayamaDepartment of Psychiatry, School of Medicine, National Defense Medical College, Saitama, Japan.
Yoshifumi KubotaKameda Medical Center Department of Infectious Diseases, Chiba, Japan.
Yoshinobu AbeDivision of Emergency and Disaster Medicine Tohoku Medical and Pharmaceutical University, Miyagi, Japan.
Yudai IwasakiDepartment of Anesthesiology and Perioperative Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Yuki KishiharaDepartment of Emergency Medicine, Japanese Red Cross Musashino Hospital, Tokyo, Japan.
Jun KataokaDepartment of Critical Care Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan.
Tetsuro NishimuraDepartment of Traumatology and Critical Care Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Hiroshi YonekuraDepartment of Anesthesiology and Pain Medicine, Fujita Health University Bantane Hospital, Aichi, Japan.
Koichi AndoDivision of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
Takuo YoshidaIntensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
Tomoyuki MasuyamaDepartment of Emergency and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Masamitsu SanuiDepartment of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
ARDS Clinical Practice Guideline 2021 committee from the Japanese Society of Intensive Care Medicine, the Japanese Respiratory Society, and the Japanese Society of Respiratory Care Medicine
Kameda Medical Center · JPHiroshima University Hospital · JPJuntendo University Urayasu Hospital · JPKeio University · JPOsaka Women's and Children's Hospital · JPJikei University School of Medicine · JPJichi Medical University Saitama Medical Center · JPKobe City Medical Center General Hospital · JPShowa University · JPFujita Health University Bantane HospitalHiroshima University · JPJichi Medical University · JPKanazawa University · JPKyoto Prefectural University of Medicine · JPMusashino Red Cross Hospital · JPNational Hospital Organization · JPSaiseikai Kumamoto Hospital · JPTohoku Medical and Pharmaceutical University · JPUniversity of Tokyo Hospital · JPHamamatsu University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021.

methodsThe 2016 edition of the Clinical Practice Guideline covered clinical questions (CQs) that targeted only adults, but the present guideline includes 15 CQs for children in addition to 46 CQs for adults. As with the previous edition, we used a systematic review method with the Grading of Recommendations Assessment Development and Evaluation (GRADE) system as well as a degree of recommendation determination method. We also conducted systematic reviews that used meta-analyses of diagnostic accuracy and network meta-analyses as a new method.

resultsRecommendations for adult patients with ARDS are described: we suggest against using serum C-reactive protein and procalcitonin levels to identify bacterial pneumonia as the underlying disease (GRADE 2D); we recommend limiting tidal volume to 4-8 mL/kg for mechanical ventilation (GRADE 1D); we recommend against managements targeting an excessively low SpO

conclusionsThis article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL: https://www.jsicm.org/publication/guideline.html ). The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries.

Indexed as

Acute lung injuryARDSClinical practice guidelineSystematic review

Identifiers

PMID35799288
PMCPMC9263056
OpenAlexW4284882838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.