Evidence map›Paper›PMID 35799279›Full record

ArticleVeterinary research2022

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation.

Andrea Rau, Bruno Passet, Johan Castille, Nathalie Daniel-Carlier, Alexandre Asset, Jérome Lecardonnel, Marco Moroldo, Florence Jaffrézic, Denis Laloë, Katayoun Moazami-Goudarzi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrea RauUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France. andrea.rau@inrae.fr.ORCID http://orcid.org/0000-0001-6469-488X
Bruno PassetUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Johan CastilleUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Nathalie Daniel-CarlierUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Alexandre AssetUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Jérome LecardonnelUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Marco MoroldoUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Florence JaffrézicUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Denis LaloëUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Katayoun Moazami-GoudarziUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.
Jean-Luc VilotteUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.

Funding

INRAE Animal Genetics department AAP.GA.2015INRAE Animal Genetics department COSI-Net
6 · The paper itself

Abstract

The Shadoo and PrP prion protein family members are thought to be functionally related, but previous knockdown/knockout experiments in early mouse embryogenesis have provided seemingly contradictory results. In particular, Shadoo was found to be indispensable in the absence of PrP in knockdown analyses, but a double-knockout of the two had little phenotypic impact. We investigated this apparent discrepancy by comparing transcriptomes of WT, Prnp

Indexed as

Prion ProteinsPrionsAnimalsMiceMice, KnockoutNerve Tissue ProteinsRecombinant ProteinsRNA, Small InterferingTranscription FactorsNerve Tissue ProteinsPrion ProteinsPrionsPrnp protein, leucyl(101), mousePrnp protein, mouseRecombinant ProteinsRNA, Small InterferingTranscription FactorslentivirusMouseprionrobustnessShadooShRNA

Identifiers

PMID35799279
PMCPMC9264527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.