Evidence map›Paper›PMID 35799274›Full record

ArticleBMC research notes2022

Effects of end-stage osteoarthritis on markers of skeletal muscle Long INterspersed Element-1 activity.

Shelby C Osburn, Matthew A Romero, Paul A Roberson, Petey W Mumford, Derek A Wiggins, Jeremy S McAdam, Devin J Drummer, S Louis Bridges, Marcas M Bamman, Michael D Roberts

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Shelby C OsburnSchool of Kinesiology, Auburn University, 301 Wire Road, Office 260, Auburn, AL, 36849, USA.
Matthew A RomeroDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.
Paul A RobersonDepartment of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Petey W MumfordSchool of Health Sciences, Lindenwood University, Saint Charles, MO, USA.
Derek A WigginsDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeremy S McAdamDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Devin J DrummerDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
S Louis BridgesDepartment of Medicine, Hospital for Special Surgery, New York, NY, USA.
Marcas M BammanDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Michael D RobertsSchool of Kinesiology, Auburn University, 301 Wire Road, Office 260, Auburn, AL, 36849, USA. mdr0024@auburn.edu.ORCID http://orcid.org/0000-0002-7359-5362
University of Alabama at Birmingham · USAuburn University · USFlorida Institute for Human and Machine Cognition · USHospital for Special Surgery · USLindenwood University · USPennsylvania State University · USUniversity of California, Los Angeles · US

Funding

Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8M
Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint ReplacementR01HD084124 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAMMAN, MARCAS M, BRIDGES, S LOUIS · 2015 to 2019
$2.6M
NICHD NIH HHS T32 HD071866NIH HHS R01HD084124NIH HHS T32HD071866
6 · The paper itself

Abstract

objectiveLong INterspersed Element-1 (L1) is an autonomous transposable element in the genome. L1 transcripts that are not reverse transcribed back into the genome can accumulate in the cytoplasm and activate an inflammatory response via the cyclic GMP-AMP (cGAS)-STING pathway. We examined skeletal muscle L1 markers as well as STING protein levels in 10 older individuals (63 ± 11 y, BMI = 30.2 ± 6.8 kg/m

resultsL1 mRNA was higher in CTL and SX compared to Y (p < 0.001 and p = 0.001, respectively). Protein expression was higher in SX versus Y for ORF1p (p = 0.002) and STING (p = 0.022). While these data are preliminary due to limited n-sizes and the lack of a BMI-matched younger control group, higher L1 mRNA expression, ORF1p and STING protein are evident in older versus younger adults. More research is needed to determine whether cGAS-STING signaling contributes to heightened muscle inflammation during aging and/or OA.

Indexed as

Long Interspersed Nucleotide ElementsMuscle, SkeletalOsteoarthritisAgedBiomarkersHumansKnee JointMiddle AgedNucleotidyltransferasesRNA, MessengerYoung AdultBiomarkersNucleotidyltransferasesRNA, MessengerLINE-1OsteoarthritisSkeletal muscleSTING

Identifiers

PMID35799274
PMCPMC9264706
OpenAlexW4284683442

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.